Phase III Randomized Study of SYNSORB Pk in Children With E. Coli-Associated Hemolytic Uremic Syndrome

Inclusion Criteria

• •PROTOCOL ENTRY CRITERIA:
• •-Disease Characteristics--
• •Clinically diagnosed E. coli-associated diarrhea-associated hemolytic uremic syndrome (HUS)
• •Diarrheal prodrome within 7 days before onset of disease
• •No HUS associated with the following: Hereditary Post-bone marrow transplantation Streptococcus pneumoniae infection
• •No prior catastrophic complications
• •-Patient Characteristics--
• •Hematopoietic: Thrombocytopenia less than 140,000/mm3 Fragmented red blood cells
• •Renal: Renal involvement (hematuria, proteinuria, or azotemia) No underlying glomerular disease
• •Other: HIV negative No pre-existing structural abnormality or dysmotility syndrome of the gastrointestinal tract No inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis)