Metabolic Flexibility as a Biomarker of Adaptation to Diet and Exercise Challenges

Exclusion Criteria

• •Women who have given birth during the previous 12 months
• •Pregnant women or women who plan to become pregnant or become pregnant during the study
• •Lactating women
• •History or presence of diabetes, kidney disease, liver disease, certain cancers, gastrointestinal, pancreatic, other metabolic diseases, or malabsorption syndromes.
• •History of bariatric or certain other surgeries related to weight control
• •Smokers or other tobacco users (for at least 6 months prior to the start of the study)
• •History of eating disorders or other dietary patterns which are not consistent with the dietary intervention (e.g., vegetarians, very low fat diets, high protein diets)
• •Volunteers who have lost 10% of body weight within the last 12 months or who plan to initiate a weight loss program during the next 10 months
• •Unable or unwilling to give informed consent or communicate with study staff
• •Self-report of alcohol or substance abuse within the past 12 months and/or current acute treatment or rehabilitation program for these problems (long-term participation in Alcoholics Anonymous is not an exclusion)
• •Other medical, psychiatric, or behavioral factors that in the judgment of the Principal Investigator may interfere with study participation or the ability to follow the intervention protocol