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Discover 19,983 clinical trials near Maryland. Find research studies in your area.
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NCT01568710
Background: \- Many people with sickle cell disease have repeated episodes of severe pain that lasts for days, requiring hospital care. These episodes, called pain crises, may be caused by changes in blood flow. Researchers want to study blood flow in people with sickle cell disease who are having a pain crisis and compare it with their blood flow after the pain crisis has resolved. They also want to compare these measurements against blood flow in healthy people who do not have sickle cell disease. Objectives: \- To study whether changes in blood flow cause pain crises in people with sickle cell disease. Eligibility: * Individuals at least 18 years of age who have sickle cell disease and are being treated for a pain crisis. * Individuals at least 18 years of age who have sickle cell disease and are not experiencing a pain crisis. * Healthy volunteers matched by age and gender with the participants who have sickle cell disease. Design: * Participants will be screened with a physical exam and medical history. Blood and urine samples will be collected. * Participants having a sickle cell pain crisis will have two visits, one during the crisis and one about 4 weeks after the crisis has resolved. * Participants not having a sickle cell pain crisis will have one or two study visits. Blood samples will be collected during at least one of these visits. * Healthy volunteers will have one or two study visits. Blood samples will be collected during at least one of these visits. * During each visit for all participants, cameras and blood flow monitoring equipment will be used to measure blood flow in the forearm. sickle cell disease.
NCT00354328
This study will examine the relationship between certain measures of heart function and exercise capacity in patients with hypertrophic cardiomyopathy (HCM). Patients who participated in NHLBI studies 01-H-0006 ("Double Blind Placebo-Controlled Study of Pirfenidone - A Novel Anti-Fibrotic Drug - in Symptomatic Patients with Hypertrophic Cardiomyopathy Associated with Left Ventricular Diastolic Dysfunction") and 96-H-0144 ("Double Blind Placebo-Controlled Study of Long-Term Effects of Angiotensin-Converting Enzyme Inhibition (Enalapril) and Angiotensin II Receptor Blockade (Losartan) on Genetically-Induced Left Ventricular Diastolic Dysfunction") are eligible for this study. Data from echocardiograms and measures of left ventricular pressure obtained from patients in those studies will be analyzed in the current study to assess their influence on exercise capacity. No additional tests, treatments or other procedures are required. Information from this study may help in the development of improved drug treatments for HCM.