Clinical Trials in Dallas

Showing 3701-3720 of 17,468 trials

A Study of AC676 for the Treatment of Relapsed/Refractory B-Cell Malignancies

NCT05780034

This clinical trial is evaluating a drug called AC676 in participants with Relapsed/Refractory B-cell Malignancies. The main goals of the study are to: * Identify the recommended dose of AC676 that can be given safely to participants * Evaluate the safety profile of AC676 * Evaluate the pharmacokinetics of AC676 * Evaluate the effectiveness of AC676

Relapsed/Refractory B-cell Malignancies

Accutar Biotechnology Inc60 participantsStarted Jun 2023

Denver, Colorado, United States • Sarasota, Florida, United States • Chapel Hill, North Carolina, United States +6 more locations

TERMINATEDPhase 1/2< 1 mile

A Study of Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

NCT04501614

This study is about an anticancer drug called ponatinib which is a tyrosine kinase inhibitor given with chemotherapy to children, teenagers, and young adults up to 21 years of age with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia who have relapsed or are resistant to other treatment. The main aims of this study are to confirm the highest dose of ponatinib tablets and minitablet capsules that can be given to participants with acceptable side effects, and to evaluate if participant's leukemia achieves remission. Participants will take ponatinib tablets with chemotherapy. For participants who cannot swallow tablets or who are receiving less than a 10 milligrams (mg) dose, a capsule with small ponatinib minitablets inside will be provided. Participants will take ponatinib for 10 weeks in combination with chemotherapy (reinduction and consolidation blocks) and will be followed up for at least 3 years.

Pediatric Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia (Ph+ALL)Ph+ Mixed Phenotype Acute Leukemia (MPAL)Philadelphia Chromosome-Like ALL (Ph-like ALL)

Takeda11 participantsStarted Feb 2021

Little Rock, Arkansas, United States • Los Angeles, California, United States • San Diego, California, United States +61 more locations

A Study of AC676 for the Treatment of Relapsed/Refractory B-Cell Malignancies

A Study of Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Find Trials by Condition in Dallas

A Study Investigating the Efficacy and Safety of LBL-007 Plus Tislelizumab in Combination With Bevacizumab Plus Fluoropyrimidine Versus Bevacizumab Plus Fluoropyrimidine in Participants With Unresectable or Metastatic Colorectal Cancer

Biobank For MS And Other Demyelinating Diseases

Phase 3, Double-blind, Randomized, Placebo-controlled Trial to Evaluate the Efficacy and Safety of AR1001 in Participants With Early Alzheimer's Disease (Polaris-AD)

A Study to Evaluate Impact of Efanesoctocog Alfa on Long-term Joint Health in Participants With Hemophilia A

A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators

Efficacy and Safety of Four Doses of Cenerimod Compared to Placebo in Adult Subjects With Active Systemic Lupus Erythematosus

Multi-Center Molecular Diagnosis and Host Response of Respiratory Viral Infections in Pediatric Transplant Recipients

Central Vein Sign: a Diagnostic Biomarker in Multiple Sclerosis

Investigation of DEXA-C Anterior Cervical Interbody System

A Study to Learn About The COVID-19 (Study) Vaccine (Called COMIRNATY) in People That Are Less Than 21 Years Old.

A Study to Evaluate ENERGI-F703 GEL in Diabetic Foot Ulcer

Study With Various Immunotherapy Treatments in Participants With Lung Cancer

Pembrolizumab With Chemotherapy and MK-4830 for Treating Participants With Ovarian Cancer (MK-4830-002)

First-in-human Study of Orally Administered KT-621 in Healthy Adult Participants

Close Assessment and Testing for Chronic Graft Versus Host Disease, CATCH Study

Tovorafenib (DAY101) Monotherapy for Patients With Melanoma and Other Solid Tumors

Surgeon-performed Ultrasound for Real-time Guidance In Oral Cancer Surgeries - A Multicenter Randomized Controlled Trial

Treating Pulmonary Embolism With Laguna Thrombectomy System (TRUST)