Medical Access Program for Datopotamab Deruxtecan in EGFRm NSCLC Patients

This is a Medical Access Program that will be available to adult patients with previously treated advanced or metastatic EGFR mutated NSCLC who have no suitable treatment options and are not able to enter a clinical trial. Patients enrolled in the Medical Access Program can continue treatment until any of the following occurs: * Disease progression * Unacceptable toxicity * The benefit-risk no longer favors the individual * Dato-DXd becomes commercially available and reimbursement is approved * The patient chooses to discontinue treatment * Withdrawal of consent * Pregnancy * Physician discretion * Death Patients enrolled in the Medical Access Program have an option to participate in collection of safety-focused clinical practice data. This will contribute towards better understanding of the clinical experience of treatment with Dato-DXd. Participation in this optional data collection will have no bearing on receipt of treatment.