Clinical Trials in Cleveland

Showing 9341-9360 of 16,969 trials

Clinical Study to Evaluate the Maximum Tolerated Dose of BAY1000394 When Given Together With Chemotherapy and the Effectiveness of This Combination Treatment in Shrinking a Specific Type of Lung Tumors (Small Cell Lung Cancer)

NCT01573338

This is the first study where BAY1000394 is given in combination with chemotherapy: cisplatin / etoposide or carboplatin / etoposide. Patients with small cell lung cancer will be treated. Every patient will receive drug treatment, there is no placebo group. Different groups of patients will receive different dosages of BAY1000394 to determine the safety and maximum tolerated dose (MTD) of BAY1000394 in combination with chemotherapy. The dose of chemotherapy is the standard dose usually administered and will not change. The study will also assess how the drug is metabolized by the body and changes in tumor size. BAY1000394 will be given per mouth, twice a day for three days every week. Treatment will stop if the tumor continues to grow, if side effects occur which the patient can not tolerate or if the patients decides to exit treatment.

Small Cell Lung Carcinoma

Bayer43 participantsStarted Feb 2013

St Louis, Missouri, United States • Buffalo, New York, United States • Cleveland, Ohio, United States +5 more locations

COMPLETEDNA< 1 mile

Pilot Study of TransAeris® System in Surgical Patients at Risk of Prolonged Mechanical Ventilation

NCT04309123

This study will be conducted as a pilot trial of the TransAeris system for the prevention and treatment of ventilator-induced diaphragm dysfunction (VIDD) in patients identified prior to surgery to be at greater risk of prolonged mechanical ventilation (PMV).

Ventilator-Induced Diaphragm Dysfunction

Synapse Biomedical40 participantsStarted Mar 2020

Cleveland, Ohio, United States

Clinical Study to Evaluate the Maximum Tolerated Dose of BAY1000394 When Given Together With Chemotherapy and the Effectiveness of This Combination Treatment in Shrinking a Specific Type of Lung Tumors (Small Cell Lung Cancer)

Pilot Study of TransAeris® System in Surgical Patients at Risk of Prolonged Mechanical Ventilation

Find Trials by Condition in Cleveland

Tivantinib Plus Erlotinib Versus Placebo Plus Erlotinib for the Treatment of Non-squamous, Non-small-cell Lung Cancer

Ancillary Effects of Dexmedetomidine Sedation After Cardiac Surgery

Lisinopril or Coreg CR® in Reducing Side Effects in Women With Breast Cancer Receiving Trastuzumab

A Study of ALKS 5461 for Treatment Refractory Major Depressive Disorder (MDD)

Rheos System for the Treatment of HFpEF Heart Failure

Ultra-Low Tidal Volume Mechanical Ventilation in ARDS Through ECMO

A Research Study to Compare Insulin 287 Once a Week to Insulin Glargine (100 Units/mL) Once a Day in People With Type 2 Diabetes.

Clinical Endpoint Bioequivalence Study of Test and Reference Inhalation Products in Patients With COPD With Device Robustness

Amifampridine Phosphate for the Treatment of Congenital Myasthenic Syndromes

A Research Study to Compare Two Types of Insulin: Insulin 287 and Insulin Glargine in People With Type 2 Diabetes Who Have Not Used Insulin Before

ARQ 197 for Participants With Relapsed or Refractory Germ Cell Tumors

Afrezza Safety and Pharmacokinetics Study in Pediatric Patients

Refametinib in Combination With Sorafenib in RAS Mutant Hepatocellular Carcinoma (HCC)

Wide Frequency Band Test of Hearing in Veterans

Cryoballoon vs. Rhythmia Guided Ablation for Recurrent AFib

Randomized, Double Blind Multicenter Phase II Study of Time to Progression on Fulvestrant in Combination With Erlotinib or Placebo in Hormone Receptor-Positive Metastatic Breast Cancer (MBC) Subjects Who Progressed on First Line Hormonal Therapy

Tisotumab Vedotin (HuMax®-TF-ADC) Safety Study in Patients With Solid Tumors

Strategy for Maintenance of HIV Suppression With Once Daily Integrate Inhibitor+Darunavir/Ritonavir in Children