Clinical Study to Evaluate the Maximum Tolerated Dose of BAY1000394 When Given Together With Chemotherapy and the Effectiveness of This Combination Treatment in Shrinking a Specific Type of Lung Tumors (Small Cell Lung Cancer)

Exclusion Criteria

• •Prior systemic anticancer therapy
• •Prior radiotherapy (local palliative radiotherapy is permitted)
• •History of cardiac disease: congestive heart failure \> NYHA Class II, unstable angina (anginal symptoms at rest), any episodes of angina or history of myocardial infarction, cardiac arrhythmias requiring anti-arrhythmic therapy (beta blockers or digoxin are permitted), previous venous or arterial thrombotic events, pulmonary embolism
• •Moderate or severe hepatic impairment, ie Child-Pugh class B or C
• •Known human immunodeficiency virus (HIV) infection or chronic hepatitis B or C