Clinical Trials in Cleveland

Showing 2581-2600 of 19,775 trials

Repeat Breast Conserving Surgery Followed by Daily Partial Breast Irradiation in Ipsilateral Breast

NCT06129747

The standard treatment for participants whose cancer has returned after breast conserving surgery is radiation given twice daily (separated by at least 6 hours) for a total of 30 treatments. The purpose of this study is to find out if giving radiation once a day for 15 treatments after repeat breast conserving surgery works as well as giving it the standard way.

Breast CancerTumor, Breast

Case Comprehensive Cancer Center55 participantsStarted Nov 2023

Cleveland, Ohio, United States • Cleveland, Ohio, United States

RECRUITINGPhase 1/2< 1 mile

A Study of TAK-188 in Adults With Advanced or Spreading Solid Tumors

NCT07205718

TAK-188 is a new medicine that targets a protein called CCR8, which is found on the surface of certain cells (Tregs) inside tumors. These cells can weaken the body's ability to fight cancer. TAK-188 may help to remove these Tregs. Removing these Tregs may allow more cancer-fighting cells (CD8+ T cells) to attack the tumor and potentially stop tumors from growing. In this study, researchers want to learn if TAK-188 can help the body's immune system better fight cancer in adults with advanced cancers which have not gotten better with regular treatments. The main aims of this study are to check if TAK-188 is safe in adults with advanced or spreading (metastatic) solid tumors, if participants tolerate the treatment with TAK-188 and to learn if TAK-188 works well in adults with certain advanced cancers after their previous treatments didn't work. Participants may receive TAK-188 for up to 1 year. Their health will be monitored after the treatment has ended for up to another year.

Advanced or Metastatic Solid Tumors

Takeda223 participantsStarted Nov 2025

Santa Monica, California, United States • New Haven, Connecticut, United States • Orlando, Florida, United States +12 more locations

Repeat Breast Conserving Surgery Followed by Daily Partial Breast Irradiation in Ipsilateral Breast

A Study of TAK-188 in Adults With Advanced or Spreading Solid Tumors

Find Trials by Condition in Cleveland

Continuous Glucose Monitoring in Polycystic Ovarian Syndrome

Suppression of Ovarian Function With Either Tamoxifen or Exemestane Compared With Tamoxifen Alone in Treating Premenopausal Women With Hormone-Responsive Breast Cancer

A Research Study to See How Well CagriSema Compared to Tirzepatide Helps People With Obesity Lose Weight

Registry of the Patient Experience for Carpal Tunnel Release

A Study to Evaluate the Safety and Effectiveness of the Rapidlink Device When Used in Patients Undergoing an Open Surgical Procedure to Repair the Aorta

A Study to Learn About the Study Medicine Called PF-07258669 in Older Adults Including Those at Risk of Malnutrition

MDR - Comprehensive Reverse/Versa Dial Ti Glenosphere

Buprenorphine Extended-Release Subcutaneous Injection (RBP-6000) in High-risk Users

Study of Efficacy and Safety of Investigational Treatments in Patients With Moderate to Severe Hidradenitis Suppurativa

Evaluation of a Non-Implanted Electrical Stimulation Device for Overactive Bladder (OAB)

CLOZAPINE Response in Biotype-1

A Study on the Effects of Exercise Therapy on Signs of Prostate Cancer

A Study of Abemaciclib (LY2835219) Plus Tamoxifen or Abemaciclib Alone in Women With Metastatic Breast Cancer

Open-label Extension Study of Zigakibart in Adults With IgA Nephropathy.

A Study to Assess Recovery and Survival of Radiolabeled Apheresis Platelet Components Treated With the INTERCEPT Blood System for Platelets With LED Illuminator.

Study of ARO-ATXN2 Injection in Adults With Spinocerebellar Ataxia Type 2

Study of ARO-DUX4 in Adult and Adolescent Patients With Facioscapulohumeral Muscular Dystrophy Type 1

Pertuzumab, Trastuzumab, Hyaluronidase-zzxf and Enzalutamide for Treatment of Metastatic Castration-Resistant Prostate Cancer