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A Study to Learn About the Study Medicine Called PF-07976016 in Adults With Obesity | Clinical Trials | Clareo Health

COMPLETEDPHASE2

A Study to Learn About the Study Medicine Called PF-07976016 in Adults With Obesity

A PHASE 2A, RANDOMIZED, DOUBLE-BLIND, SPONSOR-OPEN, PLACEBO-CONTROLLED, PARALLEL GROUP, DOSE-RANGING STUDY OF PF-07976016 TO ASSESS SAFETY AND EFFICACY IN ADULT PARTICIPANTS WITH OBESITY

NCT06717425•Pfizer

View on ClinicalTrials.gov

Summary

The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07976016) for the potential treatment of obesity. The study will compare the experiences of participants taking the study medicine (PF-07976016) to those of participants who take placebo (a lookalike substance that contains no active study medicine). The aim is to measure the body's response to the study medicine, including any changes in participants' body weight and how well they tolerate the study medicine.

Eligibility

Age

18 - 74 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Male or non-pregnant, non-breastfeeding female, 18 to 74 years of age at Visit 1
•Body Mass Index ≥30.0 kg/m2 at Visit 1, with stable body weight, defined as \<5 kg change in the 12 weeks before Visit 1
•Eligible and willing to receive required background medicine
•Willing and able to comply with all study procedures

Exclusion Criteria

•Any medical or psychiatric condition or laboratory abnormality, or recent serious illness or hospitalization, that may increase the risk of study participation or, in the investigator's judgment, make the participant inappropriate for the study including diagnosis of type 2 diabetes mellitus, type 1 or secondary forms of diabetes.
•Use of any prohibited prior or concomitant medication(s)
•Presence of specified abnormalities on diagnostic assessments including clinical laboratory tests at Visit 1.

Locations (38)

Anaheim Clinical Trials, LLC

Anaheim, California, United States

Artemis Institute for Clinical Research

San Diego, California, United States

Clinical & Translational Research Center

Aurora, Colorado, United States

University of Colorado Anschutz Medical Campus

Aurora, Colorado, United States

Westside Center for Clinical Research

Jacksonville, Florida, United States

New Horizon Research Center

Miami, Florida, United States

Renstar Medical Research

Ocala, Florida, United States

Renstar Medical Research

Ocala, Florida, United States

St Johns Center for Clinical Research

Saint Augustine, Florida, United States

Rophe Adult and Pediatric Medicine/SKYCRNG

Union City, Georgia, United States

Key Dates

Start Date

December 9, 2024

Primary Completion Date

October 23, 2025

Completion Date

January 12, 2026

Last Updated

February 6, 2026

Enrollment

263

ACTUAL participants

Conditions

Obesity

Interventions

PF-07976016

DRUG

Placebo

DRUG

Multi-Acupoint Laser Therapy for Body Shape and Composition in Obese Menopausal Women

NCT07472881

MenopausePerimenopause+2 more

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RECRUITING

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

NCT01143454

Metabolic DiseaseObesity+4 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 6, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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A Study to Learn About the Study Medicine Called PF-07976016 in Adults With Obesity

Inclusion Criteria

Exclusion Criteria

Multi-Acupoint Laser Therapy for Body Shape and Composition in Obese Menopausal Women

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

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