Clinical Trials in Cleveland

Showing 2481-2500 of 19,775 trials

Loncastuximab Tesirine and Venetoclax for Relapsed/ Refractory Non-Hodgkin Lymphoma

NCT05053659

The purpose of this study is to determine the correct dose and safety of combining two new cancer drugs, loncastuximab tesirine and venetoclax, as a treatment for relapsed or refractory B cell lymphoma.These drugs are used to treat some lymphomas, but have not yet been tested in combination for the treatment of lymphoma. The main goal of this study is to determine the safety of the combination.

Relapsed Non Hodgkin LymphomaRefractory Non-Hodgkin Lymphoma

Paolo Caimi, MD23 participantsStarted Jun 2022

Cleveland, Ohio, United States

RECRUITINGPhase 1< 1 mile

A Study Evaluating AMG 193 in Combination With Other Therapies in Participants With Advanced Gastrointestinal, Biliary Tract, or Pancreatic Cancers With Homozygous Methylthioadenosine Phosphorylase (MTAP)-Deletion (MTAPESTRY 103)

NCT06360354

The study aims to determine maximum tolerated dose (MTD) or recommended combination dose of the MTA-cooperative PRMT5 inhibitor AMG 193 administered in combination with other therapies in adult participants with metastatic or locally advanced methylthioadenosine phosphorylase (MTAP)-deleted gastrointestinal, biliary tract, or pancreatic cancers. The study also aims to determine the safety profile of AMG 193 administered in combination with other therapies in adult participants with metastatic or locally advanced MTAP-deleted gastrointestinal, biliary tract, or pancreatic cancers.

Advanced Gastrointestinal, Biliary Tract, and Pancreatic Cancers

Amgen350 participantsStarted May 2024

Bakersfield, California, United States • Duarte, California, United States • Duarte, California, United States +74 more locations

Loncastuximab Tesirine and Venetoclax for Relapsed/ Refractory Non-Hodgkin Lymphoma

A Study Evaluating AMG 193 in Combination With Other Therapies in Participants With Advanced Gastrointestinal, Biliary Tract, or Pancreatic Cancers With Homozygous Methylthioadenosine Phosphorylase (MTAP)-Deletion (MTAPESTRY 103)

Find Trials by Condition in Cleveland

REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

Ph2, Study to Assess the Safety and Efficacy of GPC 100 and Propranolol With and Without G-CSF for the Mobilization of Stem Cells in Patients With Multiple Myeloma Undergoing Autologous Stem Cell Transplant

A Trial to Evaluate the Efficacy and Safety of Different Doses of LEO 138559 in Adults With Moderate-to-severe Atopic Dermatitis

A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Non-squamous NSCLC

Study of Bitopertin in Participants With EPP or XLP (APOLLO)

A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

An Open-label Study (OLE) for Non-responders of VRDN-001-101 and VRDN-001-301

Diabetes RElated to Acute Pancreatitis and Its Mechanisms: Metabolic Outcomes Using Novel CGM Metrics

Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma

Tibulizumab Systemic Sclerosis Understanding and Response Evaluation (TibuSURE)

A Study of Calderasib (MK-1084) in KRAS Mutant Advanced Solid Tumors (MK-1084-001)

AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors

Efficacy and Safety of VB119 in Subjects With Membranous Nephropathy

Evaluation of ELU42 Topical Spray for the Treatment of Diabetic Foot Ulcers

A Study to Assess Efficacy and Safety of LB54640 in Patients With Hypothalamic Obesity

Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH

Cardiovascular Kidney and Metabolic Health Assessment and Patient Empowerment

A Safety and Efficacy Extension Study of Pertuzumab in Patients With Solid Tumors Previously Enrolled in a Hoffmann-La Roche-Sponsored Pertuzumab Clinical Trial