Clinical Trials in Boston

Showing 1881-1900 of 8,503 trials

A Phase I Intravesical PPM Therapy for NMIBC

NCT05519241

This clinical trial is to determine the safety and effectiveness of an investigational bladder cancer drug named "PLZ4-coated paclitaxel-loaded nanoscale micelle (PPM)." PPM is tiny particles that contain the chemotherapy drug paclitaxel. PLZ4 is a molecule that can possibly guide PPM to specifically target and deliver paclitaxel into and kill bladder cancer cells. In this trial, PPM will be instilled into the bladder cavity to treat bladder cancer that does not invade into the muscle layer of the bladder and that has failed the treatment of another drug BCG. Up to 29 patients will be enrolled into the trial. The main goal of this trial is to determine the dose of PPM for future clinical trials, assess the toxicity and obtain preliminary data regarding its effectiveness.

Non-muscle-invasive Bladder Cancer

VA Office of Research and Development29 participantsStarted Oct 2022

Boston, Massachusetts, United States

COMPLETEDPhase 3< 1 mile

Treatment of GVHD in Hematopoietic Stem Cell Transplant (HSCT) Recipients Using AAT Plus Corticosteroids (CS) Compared With Corticosteroids Alone

NCT04167514

Study CSL964\_5001 will investigate the efficacy of AAT with corticosteroids compared with corticosteroids alone as first line therapy for patients with high-risk acute GVHD

Graft Versus Host Disease (GVHD)

CSL Behring136 participantsStarted Jan 2020

Stanford, California, United States • Gainesville, Florida, United States • Tampa, Florida, United States +22 more locations

A Phase I Intravesical PPM Therapy for NMIBC

Treatment of GVHD in Hematopoietic Stem Cell Transplant (HSCT) Recipients Using AAT Plus Corticosteroids (CS) Compared With Corticosteroids Alone

Find Trials by Condition in Boston

Tucatinib, Trastuzumab, and Capecitabine for the Treatment of HER2+ LMD

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

A Phase II Study of Eribulin and Pembrolizumab in Soft Tissue Sarcomas

Study of PF-07265807 in Participants With Metastatic Solid Tumors.

A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Systolic Dysfunction

Symptom Management Implementation of Patient Reported Outcomes in Oncology

Clinical and Basic Investigations Into Congenital Disorders of Glycosylation

Efficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year

Life-Steps Counseling to Enhance Adherence and Engagement in PrEP Care

A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome

Acalabrutinib, Obinutuzumab and Chlorambucil in Treatment naïve CLL

A Study of the Safety, Tolerability, and Pharmacokinetics of Dolutegravir in Neonates Exposed to HIV-1

A Study to Evaluate AB308 in Combination With AB122 in Participants With Advanced Malignancies

A Study of LY3549492 in Healthy Weight Adult Participants

Proof of Concept Study of SAR443122 in Patients With Cutaneous Lupus Erythematosus

Open-Label Extension Study for Subjects With H1 Antihistamine Refractory Chronic Spontaneous Urticaria Completing Study AK006-001

A Safety and Pharmacokinetics Study of IDP-122 Lotion in Pediatric Participants With Plaque Psoriasis

Multicenter Study to Evaluate the Clinical Outcome of PrimeTaper EV Implant in Single Tooth Restorations