Clinical Trials in Boston

Showing 1821-1840 of 17,836 trials

Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration

NCT07269808

This study is a pragmatic, randomized controlled pilot trial comparing remimazolam with propofol for endoscopic procedures, designed to assess the feasibility and clinical outcomes associated with implementing a pragmatic randomized trial of sedation practices in the endoscopy setting.

AnesthesiaSedationEndoscopy

Massachusetts General Hospital100 participantsStarted Mar 2026

Boston, Massachusetts, United States

COMPLETEDNA< 1 mile

Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants

NCT05161169

This research study is exploring the use of genomic sequencing in the newborn period to screen healthy babies for current and future health risks. The study will enroll a diverse cohort of 500 healthy infants and their parents from Boston, MA; New York City, NY; and Birmingham, AL. A small blood sample will be collected from each infant, and whole genome sequencing will be performed in 1/2 of the cohort following a randomized controlled trial design. 3 months later, the randomization status and sequencing results will be shared with parents and pediatricians. Investigators will study the medical, behavioral, and economic outcomes of genomic sequencing to better understand how this technology can be implemented in outpatient primary care settings.

Genetic Predisposition to DiseaseHereditary Diseases

Brigham and Women's Hospital500 participantsStarted Dec 2022

Birmingham, Alabama, United States • Boston, Massachusetts, United States • Royal Oak, Michigan, United States +1 more locations

Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration

Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants

Find Trials by Condition in Boston

Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors

Impella ECP Study (ECP Study) and Impella ECP Continued Access Protocol

Gabapentin and Oxcarbazepine for Chronic Neuropathic Pain in Children and Adolescents: A Clinical Effectiveness Study

Medtronic Terminate AF Study

Lumason® Infusion vs. Bolus Administrations

Practical Geriatric Assessment in Older Adults With Non-Small Cell Lung Cancer Undergoing Stereotactic Body Radiation Therapy

Rate of Progression in EYS Related Retinal Degeneration

An Efficacy and Safety Study of bb2121 in Subjects With Relapsed and Refractory Multiple Myeloma and in Subjects With High-Risk Multiple Myeloma

Robotic Exosuit Augmented Locomotion (REAL)

Effect of Music on Cue Reactivity for Patients With Opioid Use Disorder

Genetic Testing in Guiding Treatment for Patients With Brain Metastases

Biospecimen Collection to Identify Gene Mutations for High Risk Pancreatic Cancer in Pediatric Patients, INSPPIRE 2 Study

mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma

Effect of Retatrutide Compared With Placebo in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Diet and Exercise Alone (TRANSCEND-T2D-1)

A Study to Evaluate Long-term Safety of Nintedanib in Children and Adolescents With Interstitial Lung Disease (InPedILD®-ON)

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of NXT007 in Persons With Severe or Moderate Hemophilia A

A Study of Pralsetinib Versus Standard of Care for First-Line Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC)

A Study to Compare Efficacy, Safety, and Immunogenicity of GME751 and EU-authorized Keytruda in Adult Participants With Untreated Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC)