Clinical Trials in Boston

Showing 11501-11520 of 15,299 trials

Validation of Mixed Venous Blood Oxygen Saturation Obtained With a Novel Mathematical Equation

NCT00783952

The purpose of this study is to test a new way to measure the oxygen level in the mixed venous blood system (the system that carries blood collected from all over the body to the heart), which is a very important monitoring tool for the overall oxygen delivery to all our tissues. This new way measures the oxygen level in the mixed venous blood from outside the body, instead of measuring from the inside through a catheter (a thin, flexible plastic tube) that is placed by breaking the skin.

Mixed Venous Oxygen SaturationTissue Oxygenation

Massachusetts General Hospital8 participantsStarted Nov 2008

Boston, Massachusetts, United States

COMPLETEDPhase 2< 1 mile

Efficacy of Mirtazapine in Depressed Cocaine Dependent Subjects

NCT00322309

This research study is being done to look at the safety of the medication Mirtazapine (Remeron) in people who have cocaine dependence and depression. Hypotheses I. Cocaine usage will be less in the mirtazapine treatment group (MG) than in the control group (CG). II. A greater increase in Clinician Global Impression (CGI) score will be observed in the MG than in the CG. Secondary Hypotheses: I. A greater decrease in Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A) scores will be observed in the MG than in the CG. II. A greater decrease in HIV risk behaviors will be observed in the MG than in the CG. III. A greater improvement in sleep structure will be observed in the MG than in the CG. IV. The proportion of subjects experiencing severe adverse drug reactions that necessitate termination from the study by one of the study clinicians will not differ between the MG and CG. V. Retention will be greater in MG than in CG.

Cocaine DependenceDepression

Boston University24 participantsStarted Sep 2005

Boston, Massachusetts, United States

Validation of Mixed Venous Blood Oxygen Saturation Obtained With a Novel Mathematical Equation

Efficacy of Mirtazapine in Depressed Cocaine Dependent Subjects

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A Study of THR-184 in Patients at Risk of Developing Cardiac Surgery Associated-Acute Kidney Injury (CSA-AKI)

Ketamine Versus Placebo for Treatment Resistant Major Depressive Disorder

Safety, Tolerability, Pharmacokinetics, and Immunoregulatory Study of Urelumab (BMS-663513) in Subjects With Advanced and/or Metastatic Solid Tumors and Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma

Ensuring Communication in Hospice by Oncology Study (ECHO)

Macrogol 3350-based Oral Osmotic Laxative in Preventing Cancer in Patients at Risk of Colorectal Cancer

Effect of Increasing Testosterone on Insulin Sensitivity in Men With the Metabolic Syndrome

Lenalidomide After Allo Transplant

Improving Antiretroviral Medication Adherence Among HIV-infected Youth: Phase I

EXTEND (Eltrombopag Extended Dosing Study)

Evaluation of Ubiquinol on Mitochondrial Oxidative Capacity in Statin Patients Using 31PMRS

Stratification of Patients With Chronic Liver Disease Using Multi Spectral CT

Dasatinib With Fludarabine and Rituximab in Relapsed and Refractory CLL and SLL

Ropinirole in the Treatment of Bipolar Depression

Thiazolidinedione Intervention With Vitamin D Evaluation

Pediatric Schizophrenia Efficacy and Safety Study

Study of Paclitaxel/Carboplatin With or Without Bavituximab in Previously Untreated Non Small-Cell Lung Cancer

Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Saxagliptin as Monotherapy in Pediatric Patients With Type 2 Diabetes

Evaluate Safety of Technosphere® Insulin (TI) in Diabetic Subjects With Moderate Obstructive Pulmonary Disease