Clinical Trials in Boston

Showing 1021-1040 of 8,503 trials

CROSSOVER STUDY OF ON-DEMAND PREP FORMULATIONS COMPARING RECTAL AND ORAL TENOFOVIR

NCT06560684

This is a Phase 2, multi-site, two-period, open label randomized crossover (Period 1 and 2) study. Participants are randomized 1:1 to one of two 8-week on-demand product sequences - TFV douche then oral F/TDF or oral F/TDF then TFV douche - with a 2 to 4-week washout period in between. Domains of safety, acceptability, adherence, and PK/PD (sub-study only) are assessed for each product.

Tenofovir

National Institute of Allergy and Infectious Diseases (NIAID)150 participantsStarted Oct 2024

Birmingham, Alabama, United States • Los Angeles, California, United States • Lawrenceville, Georgia, United States +5 more locations

RECRUITINGPHASE2< 1 mile

A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

NCT06667076

The primary purpose of the study is to assess how well amivantamab in combination with lazertinib or in combination with chemotherapy works (antitumor activity) in participants with epidermal growth factor receptor mutated (EGFRm) non-small cell lung cancer (NSCLC; that is one of the major types of lung cancer).

Carcinoma, Non-Small-Cell Lung

Janssen Research & Development, LLC480 participantsStarted Dec 2024

Daphne, Alabama, United States • Huntsville, Alabama, United States • Goodyear, Arizona, United States +175 more locations

CROSSOVER STUDY OF ON-DEMAND PREP FORMULATIONS COMPARING RECTAL AND ORAL TENOFOVIR

A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Find Trials by Condition in Boston

Prostate Active Surveillance Study

Immunotherapy With MK-3475 in Surgically Resectable Head and Neck Squamous Cell Carcinoma

A Study of Cytisinicline for Smoking Cessation in Adult Smokers

Assessment of CCM in HF With Higher Ejection Fraction

Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV

Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery

Testing the Addition of the Drug Apalutamide to the Usual Hormone Therapy and Radiation Therapy After Surgery for Prostate Cancer, INNOVATE Trial

Cerliponase Alfa Observational Study in the US

A Study Evaluating B Cell Levels In Infants Of Lactating Women With CIS Or MS Receiving Ocrelizumab

Decision Making, Daily Experiences, and Brain Activity in Young Adult Women

Removing Transfusion Dependence as a Barrier to Hospice Enrollment

Harm Reduction for Smokers With Mental Illness

Evaluating the Safety and Clinical Efficacy of the BAIBYS™ System in Intracytoplasmic Sperm Injection (ICSI)

The EVARREST® Pediatric Mild or Moderate Liver and Soft Tissue Bleeding Study

Study BT7480-100 in Patients With Advanced Malignancies Associated With Nectin-4 Expression

A Phase III, Safety, Tolerability and Efficacy of Combination Treatment of BL-8040 and Granulocyte Colony Stimulating Factor (G-CSF) as Compared to Placebo and G-CSF for the Mobilization of Hematopoietic Stem Cells for Autologous Transplantation in Subjects With Multiple Myeloma (MM)

Study of Serine Supplementation to Protect Vision in MacTel

Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors