Clinical Trials in Boston

Showing 8601-8620 of 17,836 trials

Pilot Study of Denosumab in BRCA1/2 Mutation Carriers Scheduled for Risk-Reducing Salpingo-Oophorectomy

NCT03382574

This randomized pilot early phase I trial studies how well denosumab works in BRCA1/2 mutations carriers scheduled for risk-reducing salpingo-oophorectomy. Denosumab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread.

Ovarian Carcinoma

National Cancer Institute (NCI)2 participantsStarted Mar 2019

Boston, Massachusetts, United States • New York, New York, United States • New York, New York, United States +3 more locations

COMPLETEDPhase 2< 1 mile

Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Kidney Transplant Recipients

NCT03663335

The purpose of this study is to investigate the safety, efficacy, pharmacokinetics (PK) and pharmacodynamics (PD) of three CFZ533 dose regimens in kidney transplant recipients. This study will allow assessment of the ability of CFZ533 to replace Calcineurin inhibitors (CNIs) in terms of anti-rejection efficacy, while providing better renal function with a better safety and tolerability profile. Results of this study will be used to inform the CFZ533 dose and regimen selection for investigation in later phases of clinical development.

Kidney Transplant Rejection

Novartis Pharmaceuticals418 participantsStarted Nov 2018

Los Angeles, California, United States • San Francisco, California, United States • Aurora, Colorado, United States +71 more locations

Pilot Study of Denosumab in BRCA1/2 Mutation Carriers Scheduled for Risk-Reducing Salpingo-Oophorectomy

Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Kidney Transplant Recipients

Find Trials by Condition in Boston

Ecological Momentary Assessment of Behavioral and Psychosocial Predictors of Weight Loss Following Bariatric Surgery

Evaluation of the Efficacy and Safety of Sarilumab in Patients With Polymyalgia Rheumatica

International BPA Registry

Radiation Therapy in Treating Patients With Prostate Cancer

Examining the Impacts of Parent Mightier Play

Study to Determine the Dose, the Safety and Effectiveness of a New Drug, Modified Release rhTSH, in Patients With Multinodular Goiter

A Mobile Executive Functioning Intervention for Momentary Craving in Opioid Use Disorders

Dapagliflozin in Respiratory Failure in Patients With COVID-19

Comparative Study of Non-contact Tonometers for Intraocular Pressure and Corneal Cell Thickness Measurements

Comparative Study of Specular Microscopes for Endothelial and Corneal Cell Measurements

Comparative Study of the Topcon Tonometers CT-800 and TRK-2P and the Haag-Streit Goldmann Manual Tonometer and Topcon SP-1P

Study To Assess A Radiofrequency Microneedling Device For Dermatologic Conditions

Avelumab in First-Line Maintenance Gastric Cancer (JAVELIN Gastric 100)

Study of the Safety and Efficacy of Elagolix in Women With Polycystic Ovary Syndrome

Efficacy, Safety, and Pharmacokinetic Profiles of REGN3500 Administered to Adult Patients With Moderate-to-Severe Atopic Dermatitis

A Study of LJPC-401 for the Treatment of Iron Overload in Adult Patients With Hereditary Hemochromatosis

Effect of Small Versus Large Epidural Needles on Postdural Puncture Headache Study

Expand New Drugs for TB [endTB]