Clinical Trials in Boston

Showing 7941-7960 of 17,836 trials

Genicular Artery Embolization (GAE) for the Treatment of Chronic Post Knee Arthroplasty Pain

NCT05248308

This study seeks to evaluate the safety and efficacy of genicular artery embolization (GAE) as a treatment for patients with chronic pain following primary total knee arthroplasty (TKA) or revision TKA at 6 months as measured by the Knee Injury and Osteoarthritis Outcome Score (KOOS).

Knee Pain ChronicKnee Swelling PainArterial Occlusion

Brigham and Women's HospitalStarted Jul 2022

Boston, Massachusetts, United States

TERMINATEDPhase 3< 1 mile

Effects of Oral Levosimendan on Respiratory Function in Patients With Amyotrophic Lateral Sclerosis (ALS): Open-Label Extension

NCT03948178

This study provides an opportunity for subjects in the REFALS (3119002; NCT03505021) study to continue treatment with oral levosimendan. The study will also provide more information about long-term safety and effectiveness of oral levosimendan in patients with ALS. This is an open-label study, so that all eligible subjects that complete the double-blind REFALS study (48-weeks of treatment) will have the opportunity to receive oral levosimendan treatment. The primary objective, in addition to continuing treatment for subjects enrolled in the REFALS study, is to evaluate long-term safety of oral levosimendan in ALS patients. Another important objective is to explore long-term effectiveness of oral levosimendan in the treatment of patients with ALS. This study is open only to patients taking part in the REFALS study.

Amyotrophic Lateral Sclerosis

Orion Corporation, Orion Pharma227 participantsStarted Jun 2019

Phoenix, Arizona, United States • La Jolla, California, United States • Orange, California, United States +76 more locations

Genicular Artery Embolization (GAE) for the Treatment of Chronic Post Knee Arthroplasty Pain

Effects of Oral Levosimendan on Respiratory Function in Patients With Amyotrophic Lateral Sclerosis (ALS): Open-Label Extension

Find Trials by Condition in Boston

Intravenous Ganaxolone as Adjunctive Therapy to Treat Subjects With Status Epilepticus

Pistachios and Neural Macular Pigment

Letermovir Treatment for Refractory or Resistant Cytomegalovirus Infection

A Safety Study of SGN-LIV1A in Breast Cancer Patients

Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart Failure

Achieving Diagnostic Excellence Through Prevention and Teamwork

Engaging Siblings of Adults With Autism in Future Planning

A Study of Ubenimex in Patients With Pulmonary Arterial Hypertension (WHO Group 1)

Re-Engineered Discharge for Diabetes-Computer Adaptive Testing (REDD-CAT)

iWellness Study to Evaluate a Mental Health App for Students

Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity

PF-07225570 Alone or in Combination With an Anti-PD-1 Antibody in Recurrent Non-muscle Invasive Bladder Cancer (NMIBC)

An Investigational Immuno-therapy Safety and Effectiveness Study of Nivolumab in Combination With Brentuximab Vedotin to Treat Non-Hodgkin Lymphomas

Estimation of the Prevalence of HER2 Low and Describe the SoC, Treatment Patterns, and Outcome in Real-world Practice Among Unresectable and/or Metastatic Breast Cancer Patients With HER2 Low Status

The Use of Penicillin Allergy Clinical Decision Rule to Enable Direct Oral Penicillin Challenge

A Study Evaluating the Safety and Efficacy of Upadacitinib in Adults With Active Ankylosing Spondylitis

Gene Therapy for Achromatopsia (CNGB3)

A PK, Safety and Tolerability Study of Peripheral and Central Infusion of Melflufen in RRMM Patients