Clinical Trials in Boston

Showing 7761-7780 of 17,836 trials

A Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple- Dose BIVV009 in Participants With Chronic Immune Thrombocytopenia (ITP)

NCT03275454

The purpose of this study is to explore the safety, preliminary clinical benefit, and activity of BIVV009 in patients with chronic immune thrombocytopenia.

Purpura, Thrombocytopenic, Idiopathic

Bioverativ, a Sanofi company12 participantsStarted Aug 2017

Georgetown, District of Columbia, United States • Boston, Massachusetts, United States • Pittsburgh, Pennsylvania, United States +2 more locations

COMPLETEDPhase 2< 1 mile

Cannabidiol Use to Reduce Cravings in Individuals With Opioid Use Disorder on Buprenorphine

NCT04192370

The purpose of this week-long study is to determine the impact of cannabidiol on cue-induced cravings among individuals with opioid use disorder who are stable on sublingual buprenorphine treatment.

Opioid-use Disorder

Brigham and Women's Hospital8 participantsStarted Aug 2020

Boston, Massachusetts, United States

COMPLETEDNA< 1 mile

Confocal Endomicroscopy for Improved Diagnosis of Barrett's Esophagus and Early Esophageal Cancer(CEBE Study)

NCT01124214

Endomicroscopy (EM) can improve the diagnosis Barrett's esophagus (BE) and some early esophageal cancers (Intra Epithelial Neoplasia (IEN)). EM provides optical biopsies comparable to standard histology. Specifically, EM allows targeted biopsy rather than random mucosal biopsy during routine endoscopic surveillance of BE or evaluation EIN, which will improve the diagnostic yield of mucosal samples for BE IEN. Furthermore, when combined with high resolution endoscopy, EM may improve the overall in vivo detection of IEN in lesions as well as flat mucosa. EM will provide accurate place and size of IEN which will impact the physician's decision to biopsy or perform endoscopic mucosal resection (EMR). This could potentially minimize the number of unnecessary biopsies and as well as enable the physician to perform EMR at the time of the initial examination, rather than delaying endoscopic treatment after the pathology is available. This study is important because it will validate single center studies supporting the routine use of EM for screening and surveillance of BE.

Barrett's Esophagus, Esophageal Intraepithelial Neoplasia

Johns Hopkins University68 participantsStarted Jul 2010

Boston, Massachusetts, United States • New York, New York, United States • Philadelphia, Pennsylvania, United States +1 more locations

A Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple- Dose BIVV009 in Participants With Chronic Immune Thrombocytopenia (ITP)

Cannabidiol Use to Reduce Cravings in Individuals With Opioid Use Disorder on Buprenorphine

Confocal Endomicroscopy for Improved Diagnosis of Barrett's Esophagus and Early Esophageal Cancer(CEBE Study)

Find Trials by Condition in Boston

Study of ABT-199 (GDC-0199) in Combination With Azacitidine or Decitabine (Chemo Combo) in Subjects With Acute Myelogenous Leukemia (AML)

HBV-HIV Coinfection Research Network

Study to Evaluate the Efficacy and Safety of Remdesivir in Participants With Severely Reduced Kidney Function Who Are Hospitalized for Coronavirus Disease 2019 (COVID-19)

Momelotinib Versus Ruxolitinib in Subjects With Myelofibrosis

Hospital-wide Incidence, Clinical Characteristics and Outcomes of ARDS

Bevacizumab Plus Ipilimumab in Patients With Unresectable Stage III or IV Melanoma

Virtual Cardiac Wellness Program Following Hypertensive Disorders of Pregnancy

Study of ASN003 in Subjects With Advanced Solid Tumors

Willingness to Participate in Clinical Trials Among Black and African Americans

A Clinical Study Evaluating the Safety and Efficacy of SI-614 Ophthalmic Solution in Patients With Dry Eye

Safety, Tolerability, and Pharmacodynamics of NOV-001 in Adult Subjects

A 3-week Study Investigating Patient Use and Functionality of Formoterol in a Novel Inhalation Device in Patients With Asthma

A PRospective, rAndomizEd Comparison of subcuTaneOous and tRansvenous ImplANtable Cardioverter Defibrillator Therapy

Clinical Trial Evaluating ITI-007 as an Adjunctive Therapy to Lithium or Valproate for the Treatment of Bipolar Depression

Safety, Tolerability, and Exploratory Efficacy of Adjunctive EQU-001 for Seizures in Adults With Epilepsy

Safety and Effectiveness of the XEN45 Glaucoma Treatment System in Patients With Angle Closure Glaucoma

Accessorized Pre-Filled Syringe to Autoinjector Pharmacokinetic Bridging Study in Anifrolumab