Clinical Trials in Boston

Showing 7761-7780 of 13,548 trials

A Dose-finding Study of a Combination of Imatinib and BKM120 in the Treatment of 3rd Line GIST Patients

NCT01468688

The purpose of this study is to determine a maximum tolerated dose and/or recommended phase 2 dose of a combination of imatinib and BKM120 in the treatment of 3rd line GIST patients.

3rd Line GIST

Novartis Pharmaceuticals60 participantsStarted Apr 2012

Boston, Massachusetts, United States • Seattle, Washington, United States • Leuven, Belgium +8 more locations

TERMINATEDPhase 1< 1 mile

Study of Safety and Efficacy of Ribociclib and Trametinib in Patients With Metastatic or Advanced Solid Tumors

NCT02703571

Phase Ib dose escalation in advanced solid tumors to identify dose for Phase II dose expansion in advanced or metastatic pancreatic cancer and KRAS-mutant colorectal cancer. Open-label, nonrandomized.

Solid Tumors for Phase IbPancreatic Cancer for Phase IIColorectal Cancer for Phase II

Novartis Pharmaceuticals95 participantsStarted Jun 2016

Fayetteville, Arkansas, United States • Duarte, California, United States • New Haven, Connecticut, United States +12 more locations

A Dose-finding Study of a Combination of Imatinib and BKM120 in the Treatment of 3rd Line GIST Patients

Study of Safety and Efficacy of Ribociclib and Trametinib in Patients With Metastatic or Advanced Solid Tumors

Find Trials by Condition in Boston

Combination of RAD001 and Erlotinib in Patients With Advanced Non Small Cell Lung Cancer Previously Treated Only With Chemotherapy

Safety and Efficacy of QAX576 in Patients With Idiopathic Pulmonary Fibrosis (IPF)

Phase I Study LJM716 Combined With Trastuzumab in Patients With HER2 Overexpressing Metastatic Breast or Gastric Cancer

Safety and Efficacy Study of Oral Fosfomycin Versus Oral Levofloxacin to Treat Complicated Urinary Syndromes (FOCUS)

Phase I/IIa Study of FIXFc in Hemophilia B Patients

Efficacy, Safety, and Pharmacokinetics of QAW039

Safety Study of LBH589 When Given in Combination With Lenalidomide and Dexamethasone in Adult Patients With Multiple Myeloma.

Study of INC280 in Patients With c-MET Dependent Advanced Solid Tumors

Efficacy of QAX576 in Asthma

Pharmacokinetics and Safety of Single Subcutaneous Pasireotide (SOM230) in Subjects With Varying Degrees of Hepatic Function

The Long-term Study to Evaluate the Safety of Eplerenone in the Treatment of Hypertension in Children Aged 6 to 16 Years

Efficacy, Safety, Tolerability, and Pharmacokinetics of Sotrastaurin Combined With Tacrolimus vs. a Mycophenolic Acid-tacrolimus Regimen in Renal Transplant Patients

A Phase I, Multi-center, Open Label, Drug-drug Interaction Study to Assess the Effect of Ceritinib on the Pharmacokinetics of Warfarin and Midazolam in Patients With ALK-positive Advanced Tumors

Evaluation of Renal Function Impairment on the Pharmacokinetics of LEE011

A Trial l of Panobinostat Given in Combination With Trastuzumab and Paclitaxel in Adult Female Patients With HER2 Positive Metastatic Breast Cancer

Effect of Hepatic Impairment on LDE225..

PCA062 in pCAD-positive Tumors.

Pharmacokinetics of rFVIIIFc at Two Vial Strengths