Clinical Trials in Boston

Showing 6741-6760 of 17,836 trials

A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AG-946 in Healthy Volunteers and in Participants With Sickle Cell Disease

NCT04536792

The purpose of the study is to assess the safety and tolerability of AG-946 in healthy volunteers after oral administration of single ascending doses (SAD) and multiple ascending doses (MAD) of AG-946 over 14 or up to 28 days of dosing, and to identify a range of doses that are safe and pharmacologically active in participants with sickle cell disease. The SAD and MAD parts of the study will be randomized and double-blinded, and will assess the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of AG-946 as well as the effect of food (SAD only) on the pharmacokinetics (PK) of AG-946. The sickle cell disease (SCD) part of the study will be non-randomized and open-label, and is designed to identify 1 or more safe and tolerable dose(s) of AG-946 with potential activity in the treatment of participants with sickle cell disease (SCD).

Healthy VolunteersAnemia, Sickle Cell

Agios Pharmaceuticals, Inc.122 participantsStarted Jul 2020

La Jolla, California, United States • Boston, Massachusetts, United States • Boston, Massachusetts, United States +7 more locations

COMPLETEDNA< 1 mile

Improving Health and Environmental Health Literacy of Professionals

NCT05879666

The goal of this clinical trial is to understand the impact of an educational intervention on reproductive health care providers' environmental health literacy related to phthalates. The main questions to answer are: 1. Does a web-based educational intervention improve the environmental health literacy of personal care product chemicals based on pre/post/post intervention survey data? 2. Does a web-based educational intervention improve reproductive health professionals' confidence and awareness for communication to patients on environmental health literacy? 3. Do concentrations of personal care product chemicals in reproductive health professionals decrease after the web-based educational intervention? Participants will be asked to complete three surveys: one before the educational intervention, and two after the intervention. The will be asked to complete the approximately 1-hour online educational intervention, which consists of a series of videos from the perspectives of patients, OBGYNs, and researchers, an interactive module, and a worksheet to facilitate conversation with patients.

Health Knowledge, Attitudes, Practice

Harvard School of Public Health (HSPH)213 participantsStarted Jun 2023

Boston, Massachusetts, United States

A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AG-946 in Healthy Volunteers and in Participants With Sickle Cell Disease

Improving Health and Environmental Health Literacy of Professionals

Find Trials by Condition in Boston

The Safety and Efficacy Study of Ethylenediaminetetraacetic Acid (EDTA) Ophthalmic Solution in Patients With Loss of Contrast Sensitivity Due to Age-Related, Low-Grade Nuclear Cataract

Feasibility of an Electrical Impedance Tomography Device for Pulmonary Function Testing in ALS Patients

BI 894999 First in Human Dose Finding Study in Advanced Malignancies

Selective Fetal Growth Restriction in Monochorionic Twins - an International Investigation

Genomic Determinants and Shared Genetic Pathways of Periodontal Disease

Buspirone and Melatonin for Depression Following Traumatic Brain Injury

Phase I/IIa Study of H002 in NSCLC With Active EGFR Mutation

Open-Label Extension Study of Trofinetide for the Treatment of Girls and Women With Rett Syndrome

Study to Evaluate the Safety and Pharmacokinetics of Efmarodocokin Alfa in Combination With Standard of Care in Participants Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Assessment of Right Ventricular Volume in Pediatric Patients

Study to Assess the Efficacy and Safety of Orismilast in Psoriasis

Assessment of Left Ventricular Filling Pressure by Applying Artificial Intelligence Algorithms to Left Atrial Speckle-tracking Echocardiography

The Pristine Post-Market Study

Digital Health Intervention to Support Opioid Use Disorder Treatment

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of BFKB8488A Compared With Placebo in Participants With Non-Alcoholic Steatohepatitis

Safety, Tolerability, and Pharmacokinetics of UX053 in Patients With Glycogen Storage Disease Type III (GSD III)

Long-Term Follow-Up Gene Therapy Study for Leber Congenital Amaurosis OPTIRPE65 (Retinal Dystrophy Associated With Defects in RPE65)

Study to Evaluate Romosozumab in Children and Adolescents With Osteogenesis Imperfecta