Clinical Trials in Boston

Showing 5161-5180 of 17,836 trials

Assessment of a Non-invasive Device in the Management of Open Abdomen (AbCLO)

NCT06242925

The goal of this multicenter, prospective Cohort Interventional study is to perform a pilot study of the AbCLO (Abdominal Wall Closure) device in patients with Open Abdomen. The main question it aims to answer is: • Does the Abdominal Wall Closure Device (AbCLO) increase the likelihood of primary facial closure in cases of open abdomen when compared to historical controls? Participants will be cases of open abdomen who underwent emergency surgery for Trauma or Acute Care Surgery, will have the AbCLO device. These will be compared to historical controls managed at the same center.

Open Abdomen

Tufts Medical Center20 participantsStarted Feb 2024

Los Angeles, California, United States • Boston, Massachusetts, United States

RECRUITINGPhase 2< 1 mile

DALY II USA/ MB-CART2019.1 for DLBCL

NCT04792489

DALY II USA is a phase II, multi-center, single arm study to evaluate the efficacy, safety, and pharmacokinetics of zamtocabtagene autoleucel (MB-CART2019.1) in patients with relapsed and/or refractory diffuse large B cell lymphoma (DLBCL) after receiving at least two lines of therapy. Additional cohorts include subjects with B-cell primary or secondary central nervous system (CNS) lymphoma (PCNSL) and (SCNSL), mantle cell lymphoma (MCL) and Richter's transformation (RT) after receiving at least one line of therapy.

Refractory Diffuse Large B Cell Lymphoma (DLBCL)Relapsed Diffuse Large B Cell LymphomaHigh Grade B-cell Lymphoma (HGBCL)+5 more

Miltenyi Biomedicine GmbH248 participantsStarted May 2021

Gilbert, Arizona, United States • Phoenix, Arizona, United States • La Jolla, California, United States +22 more locations

Assessment of a Non-invasive Device in the Management of Open Abdomen (AbCLO)

DALY II USA/ MB-CART2019.1 for DLBCL

Find Trials by Condition in Boston

Efficacy Study of Nivolumab Compared to Ipilimumab in Prevention of Recurrence of Melanoma After Complete Resection of Stage IIIb/c or Stage IV Melanoma

Genes and Environment in Multiple Sclerosis

Carbohydrate Beta Cell Function and Glucose Control in Children With Diabetes

Long-term Follow-up Study With Darvadstrocel in the Treatment of Complex Perianal Fistula

A Study to Verify the Clinical Benefit of Aducanumab in Participants With Early Alzheimer's Disease

Study of REM-422 in Patients With AML or Higher Risk MDS

Treatment of Persistent Atrial Fibrillation With Sphere-9 Catheter and Affera Mapping and Ablation System

HiLo: Pragmatic Trial of Higher vs Lower Serum Phosphate Targets in Patients Undergoing Hemodialysis

Predictive Analytics and Clinical Decision Support to Improve PrEP Prescribing

The Hope App Study

Asthma Link Effectiveness Trial

Carvedilol in Preventing Heart Failure in Childhood Cancer Survivors

A Trial of Setanaxib in Patients With Primary Biliary Cholangitis (PBC) and Liver Stiffness

MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Sclerosis (ALS)

A Multiple-dose Study of ASP8374, an Immune Checkpoint Inhibitor, as a Single Agent and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

Clinical Trial Readiness to Solve Barriers to Drug Development in FSHD

A Study of BI-1206 in Combination With Rituximab With or Without Acalabrutinib in Subjects With Indolent B-Cell NHL

Phase 2b Study of MBS2320 in Participants With Methotrexate-Refractory RA