Clinical Trials in Boston

Showing 4681-4700 of 17,836 trials

Hydrogen's Feasibility and Safety as a Therapy in ECPR

NCT05574296

The purpose of this project is to test the feasibility and safety of inhaled hydrogen gas (H2) administration as a rescue therapy during cardiac arrest requiring extracorporeal cardiopulmonary resuscitation (ECPR, i.e. mechanical circulatory support). Under exemption from informed consent, patients undergoing refractory cardiac arrest in the cardiac ICU at a participating center will be randomized to standard therapy with or without the administration of 2% hydrogen in gases administered via the ventilator and ECMO membrane for 72 hours.

Cardiac ArrestExtracorporeal Membrane OxygenationReperfusion Injury

Boston Children's Hospital53 participantsStarted Mar 2024

Washington D.C., District of Columbia, United States • Boston, Massachusetts, United States • Kansas City, Missouri, United States +1 more locations

Active Not RecruitingPhase 2< 1 mile

DARA RVD For High Risk SMM

NCT04775550

The purpose of this research study is to learn whether the combination of daratumumab SC ( Darzalex Faspro), lenalidomide (Revlimid), bortezomib (Velcade) and dexamethasone works in treating smoldering multiple myeloma and preventing progression to active or symptomatic multiple myeloma. The names of the study drugs involved in this study are: * Daratumumab (also called Darzalex Faspro) * Bortezomib (also called Velcade) * Lenalidomide (also called Revlimid) * Dexamethasone

High-risk Smoldering Multiple MyelomaMultiple Myeloma

Omar Nadeem, MD61 participantsStarted Mar 2021

Stamford, Connecticut, United States • Boston, Massachusetts, United States • Boston, Massachusetts, United States +3 more locations

Hydrogen's Feasibility and Safety as a Therapy in ECPR

DARA RVD For High Risk SMM

Find Trials by Condition in Boston

Relapsing Forms of Multiple Sclerosis (RMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (GEMINI 1)

A Study to Investigate LYL845 in Adults With Solid Tumors

A Study to Evaluate Guselkumab for the Treatment of Participants With New-onset or Relapsing Giant Cell Arteritis

Distal Radius Interventions for Fracture Treatment

Safety, Tolerability & Potential Anti-cancer Activity of Increasing Doses of AZD5363 in Different Treatment Schedules

Study to Evaluate the Safety and Effectiveness of GP0116

DAYBREAK: A Study of Setmelanotide in Participants With Specific Gene Variants in the Melanocortin-4 Receptor (MC4R) Pathway

Rhode Island Diastolic Dysfunction - Heart Failure

DISSECT-N Post Market Data Collection Registry

Study to Evaluate the Efficacy, Safety, and Tolerability of Luvadaxistat in Participants With Cognitive Impairment Associated With Schizophrenia

A Phase III Trial of With Marizomib in Patients With Newly Diagnosed Glioblastoma

Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)

24 Weeks Double-blind Randomized Placebo-controlled Trial to Evaluate Efficacy, PK, Safety of LOU064 in Adolescents (12 - <18) With CSU and Inadequate Response to H1-antihistamine Followed by Optional 3 Years Open-label Extension and an Optional 3 Years Safety Long-term Treatment-free Follow-up

A Study of EDP-938 in Non-hospitalized Adults With RSV Who Are at High Risk for Complications.

DOAC in Unusual Site Venous Thrombosis

Personalized AZithromycin/metronidAZole Therapy in Pediatric Crohn's Disease (CD)

Study of BMF-219, a Covalent Menin Inhibitor, in Adult Patients With AML, ALL (With KMT2A/ MLL1r, NPM1 Mutations), DLBCL, MM, and CLL/SLL

Pivotal Study of the Vienna Transcatheter Self Expandable Aortic Valve SE System