Clinical Trials in Boston

Showing 4001-4020 of 13,548 trials

Exercise Training in Transthyretin Cardiac Amyloidosis

NCT05797857

Transthyretin cardiac amyloidosis causes debilitating heart failure in older adults. The proposed research will develop a personalized exercise training program to improve functional capacity in patients on optimal treatment for transthyretin cardiac amyloidosis. This is a vital next step to improve functional capacity and quality of life of people suffering from transthyretin cardiac amyloidosis.

Amyloid CardiomyopathyTransthyretin Cardiac Amyloidosis

Brigham and Women's Hospital40 participantsStarted Jul 2024

Boston, Massachusetts, United States

COMPLETEDPhase 1/2< 1 mile

p53 Suppressor Activation in Recurrent High Grade Serous Ovarian Cancer, a Phase Ib/II Study of Systemic Carboplatin Combination Chemotherapy With or Without APR-246

NCT02098343

The purpose of this study is to make a preliminary assessment of the efficacy of a combined APR-246 and carboplatin/PLD chemotherapy regimen, compared with carboplatin/PLD chemotherapy regimen alone, in patients with platinum sensitive recurrent high grade serous ovarian cancer (HGSOC) with mutated p53. In addition, the study aims to assess the safety profile of the combined APR-246 and carboplatin/PLD chemotherapy regimen compared with carboplatin/PLD chemotherapy regimen alone, to evaluate potential biomarkers, and to assess the biological activity in tumor and surrogate tissues. The trial will enroll up to a maximum of 400 patients.

Platinum Sensitive Recurrent High-grade Serous Ovarian Cancer With Mutated p53

Aprea Therapeutics247 participantsStarted Mar 2014

Los Angeles, California, United States • Chicago, Illinois, United States • Boston, Massachusetts, United States +52 more locations

Exercise Training in Transthyretin Cardiac Amyloidosis

p53 Suppressor Activation in Recurrent High Grade Serous Ovarian Cancer, a Phase Ib/II Study of Systemic Carboplatin Combination Chemotherapy With or Without APR-246

Find Trials by Condition in Boston

A Study of Etigilimab and Nivolumab in Participants With Locally Advanced or Metastatic Tumors

Safety, Tolerability and Immune Effects of the Nasal Foralumab in Healthy Human Volunteers

An Open-Label Study Following Oral Dosing of Seladelpar to Subjects With Primary Biliary Cholangitis (PBC) and Hepatic Impairment (HI)

Neural Mechanisms of Spatial Representations Beyond the Self

Evaluating the Impact of a Novel Cannabinoid Product for Endometriosis

The TRANQUILITY 2 Trial: A Phase 3 Clinical Trial to Assess the Efficacy and Safety in Subjects With Dry Eye Disease

Remote Approaches for Optimizing Weight Loss (Elevate Weight Loss Trial)

A Study to Assess the Efficacy, Safety, and Tolerability of KPL-716 in Reducing Pruritus in Chronic Pruritic Diseases

A Study of LY3561774 in Participants With Mixed Dyslipidemia

A Study of INCB050465 in Relapsed or Refractory Follicular Lymphoma

A Study of BMS-986442 With Nivolumab With or Without Chemotherapy in Solid Tumors and Non-small Cell Lung Cancer

PSMA PET/CT Guided Intensification of Therapy in Patients at Risk of Advanced Prostate Cancer

Safety and Immunogenicity of Quadrivalent Influenza mRNA Vaccine MRT5410 in Adult Participants 18 Years of Age and Older

Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy Trial of BNT411

A Study to Evaluate the Safety of mRNA-0184 in Participants With Heart Failure

Angio-IMR and Cardiac MR-derived MVO in STEMI Patients

Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function

Pivotal, Clinical Study for the Accuracy Evaluation of the IdentiClone Dx TRG Assay