Rheumatoid Arthritis Clinical Trials

Showing 14881-14900 of 47,334 trials

Use of Vasopressin Following the Fontan Operation

NCT02975999

The purpose of this pilot study is to prepare for a larger study to determine whether Vasopressin following the Fontan operation will decrease chest tube output and duration.

Pleural EffusionSingle-ventricle

Wake Forest University Health Sciences12 participantsStarted Dec 2016

Oak Lawn, Illinois, United States

TERMINATEDPhase 1/2

First-in-Human (FIH) Trial of GEN3009 in Subjects With Relapsed or Refractory B-Cell Non-Hodgkin Lymphomas

NCT04358458

The drug that will be investigated in the study is an antibody, GEN3009. Since this is the first study of GEN3009 in humans, the main purpose is to evaluate safety. Besides safety, the study will determine the recommended GEN3009 dose to be tested in a larger group of patients and assess preliminary clinical activity of GEN3009. GEN3009 will be studied in a broad group of cancer patients, having different kinds of lymphomas. All patients will get GEN3009 either as a single treatment (monotherapy) or in combination with another antibody-candidate for treatment of cancer in the blood. The study consists of two parts: Part 1 tests increasing doses of GEN3009 ("escalation"), followed by Part 2 which tests the recommended GEN3009 dose from Part 1 ("expansion").

Diffuse Large B-cell LymphomaFollicular LymphomaMarginal Zone Lymphoma+5 more

Genmab46 participantsStarted Mar 2020

Denver, Colorado, United States • Cleveland, Ohio, United States • Columbus, Ohio, United States +14 more locations

Use of Vasopressin Following the Fontan Operation

First-in-Human (FIH) Trial of GEN3009 in Subjects With Relapsed or Refractory B-Cell Non-Hodgkin Lymphomas

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