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Investigation of Clot in Ischemic Stroke and Hematoma Evacuation

NCT04693767•Penumbra Inc.

Summary

The aim of the study is to collect and analyze specimen from ischemic stroke patients undergoing thrombectomy procedures and from patients undergoing minimally invasive surgery for intracranial hematoma evacuation.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•≥ 18 Years of Age
•Frontline treatment with: Penumbra System for ischemic stroke patients eligible for mechanical thrombectomy or Artemis Neuro Evacuation device for intracranial hematoma evacuation in patients eligible for minimally invasive surgery (MIS)
•Extracted thrombus/embolus
•Informed consent is obtained from either the patient or legally authorized representative (LAR)

Exclusion Criteria

•Pregnancy or positive pregnancy test according to site routine practice (only required for women of child bearing potential; serum or urine acceptable)
•Currently participating in an investigational drug or device clinical trial that may confound the ability to capture clot and/or influence clot composition. Patients in observational, natural history, and/or epidemiological studies not involving intervention are eligible

Locations (27)

Banner Desert Medical Center

Mesa, Arizona, United States

Banner University Medical Center - Phoenix

Phoenix, Arizona, United States

Christiana Care

Newark, Delaware, United States

George Washington University

Washington D.C., District of Columbia, United States

Baptist Medical Center

Jacksonville, Florida, United States

Northwestern University

Chicago, Illinois, United States

Indiana University Health Methodist Hospital

Indianapolis, Indiana, United States

University of Kentucky

Lexington, Kentucky, United States

Norton Neuroscience Institute

Louisville, Kentucky, United States

MaineHealth

Portland, Maine, United States

Key Dates

Start Date

February 16, 2021

Primary Completion Date

July 22, 2022

Completion Date

August 3, 2022

Last Updated

October 23, 2024

Enrollment

400

ACTUAL participants

Conditions

Ischemic StrokeIntracranial Hematoma

Interventions

Mechanical thrombectomy

DEVICE

Minimally invasive surgery

OTHER

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LWP779 in Healthy Participants

NCT07371455

Ischemic Stroke

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RECRUITINGPHASE3

Tenecteplase Before Interhospital Transfer for EVT in Acute Anterior Circulation LVO at 4.5-24 Hours

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Acute Ischemic StrokeLarge Vessel Occlusion+1 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 23, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Investigation of Clot in Ischemic Stroke and Hematoma Evacuation

Inclusion Criteria

Exclusion Criteria

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LWP779 in Healthy Participants

Tenecteplase Before Interhospital Transfer for EVT in Acute Anterior Circulation LVO at 4.5-24 Hours

Optimizing Reperfusion to Improve Outcomes and Neurologic Function

Prospective Randomized Observer Blinded Single Center Study Comparing 90-day Functional Outcome in Patients Who Received Intravenous Propofol Infusion Versus Inhalational Sevoflurane for General Anesthesia During Mechanical Thrombectomy in Patients Who Suffered From Acute Ischemic Stroke

18F FDG and 68Ga FAPI PET/MR Imaging of Carotid Artery Plaque Vulnerability: A Clinical Study in Carotid Artery Plaque Patients

Brain, Blood And Clot or Tissue Registry And Collaboration