Rheumatoid Arthritis Clinical Trials in Philadelphia

Showing 481-500 of 1,834 trials

ACTIVE_NOT_RECRUITINGPHASE1/PHASE2< 1 mile

Phase 1/2 Trial of Gavo-cel (TC-210) in Patients With Advanced Mesothelin-Expressing Cancer

NCT03907852

Gavocabtagene autoleucel (gavo-cel; TC-210) is a novel cell therapy that consists of autologous genetically engineered T cells expressing a single-domain antibody that recognizes human Mesothelin, fused to the CD3-epsilon subunit which, upon expression, is incorporated into the endogenous T cell receptor (TCR) complex. This Phase 1/2 study aims to establish the recommended Phase 2 dose (RP2D) and subsequently evaluate the efficacy of gavo-cel, with and without immuno-oncology agents, in patients with advanced mesothelin-expressing cancers, with overall response rate and disease control rate as the primary Phase 2 endpoints.

MesotheliomaMesothelioma, MalignantMesothelioma; Pleura+8 more

TCR2 Therapeutics57 participantsStarted Apr 2019

San Francisco, California, United States • Miami, Florida, United States • Chicago, Illinois, United States +8 more locations

RECRUITINGPHASE3< 1 mile

An Efficacy, Safety, and Tolerability Study of VX-880 in Participants With Type 1 Diabetes With a Kidney Transplant

NCT06832410

This study will evaluate the efficacy, safety, and tolerability of VX-880 in participants with Type 1 Diabetes (TID) with a kidney transplant.

Type 1 DiabetesKidney Transplant

Vertex Pharmaceuticals Incorporated10 participantsStarted Mar 2025

Philadelphia, Pennsylvania, United States • Pittsburgh, Pennsylvania, United States • Madison, Wisconsin, United States +4 more locations

Phase 1/2 Trial of Gavo-cel (TC-210) in Patients With Advanced Mesothelin-Expressing Cancer

An Efficacy, Safety, and Tolerability Study of VX-880 in Participants With Type 1 Diabetes With a Kidney Transplant

Rheumatoid Arthritis Trials in Other Cities

Flu Vaccine Responses in the Setting of Melanoma Treatment

EHR-integrated rUTI Texting Platform

Actis Total Hip System 2 Year Follow-up

A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors

Study of Relugolix in Men With Metastatic Castration-Sensitive Prostate Cancer or Non-Metastatic or Metastatic Castration-Resistant Prostate Cancer

A Study of Tirzepatide (LY3298176) in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF) and Obesity: The SUMMIT Trial

Study of EYP-1901 in Patients With Nonproliferative Diabetic Retinopathy (NPDR)

Study of JK07 in Patients With Chronic Heart Failure

19(T2)28z1xx Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell Cancers

Safety and Efficacy Study of Inhaled Carbon Monoxide to Treat Acute Respiratory Distress Syndrome (ARDS)

Blinatumomab and Nivolumab With or Without Ipilimumab in Treating Patients With Poor-Risk Relapsed or Refractory CD19+ Precursor B-Lymphoblastic Leukemia

Oral Contraceptive Pill (OCP) Pharmacogenomics

Air Optix Plus HydraGlyde Multifocal Daily/Extended Wear Contact Lenses

A Long-Term Follow-Up Observational Study to Evaluate Safety in Subjects Who Have Received a Gene-Modified Regulatory T Cell (Treg) Therapeutic

A Study of XPro1595 in Patients With Early Alzheimer's Disease With Biomarkers of Inflammation

A Study to Evaluate the Effect of Ustekinumab on Cytochrome P450 Enzyme Activities Following Induction and Maintenance Dosing in Participants With Active Crohn's Disease or Ulcerative Colitis

Study of INV-102 Ophthalmic Solution in Adults With Acute Infectious Keratoconjunctivitis

The ReTAVI Prospective Observational Registry

Other Conditions in Philadelphia