Have a history and current diagnosis of type 1 or type 2 diabetes mellitus.
Have an HbA1c \<11% and on a stable regimen for treatment of diabetes at least 90 days prior to screening
Have a body mass index at screening of ≤40 kilogram per meter squared (kg/m2)
You may not be if
Are pregnant or breastfeeding
Have a history of other potentially causative and/or confounding sources of pain that may impair self-assessment of pain due to diabetic peripheral neuropathic pain (DPNP)
Have lower limb amputation due to diabetes inclusive of great toe (metatarsal bone)
Have serum vitamin B12 ≤200 picogram per milliliter (pg/mL)
Have an abnormal BP (systolic BP \>140 mm Hg and diastolic BP\>90 mm Hg) at screening
Have history or current clinically significant cardiac disease, including arrhythmia, aortic aneurysm, heart failure, current electrolyte abnormalities, or any other conditions that could predispose to arrhythmia in the judgement of the investigator
Clareo Health | A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Diabetic Peripheral Neuropathic Pain