PTSD Clinical Trials

Showing 101-120 of 492 trials

Project COMET: Massed Prolonged Exposure for PTSD and SUD

NCT06968832

The goal of this clinical trial is to learn if Massed Prolonged Exposure Therapy (M-PE) can improve PTSD symptoms and reduce substance use in adults receiving intensive outpatient (IOP) treatment for substance use disorder (SUD). The main questions it aims to answer are: * Does M-PE reduce PTSD symptoms more effectively than trauma treatment as usual (TAU)? * Does M-PE reduce the number of days participants use substances? * How do patient-centered outcomes (such as depression, suicidal thoughts, and quality of life) differ between M-PE and trauma TAU? * Researchers will compare M-PE to treatment as usual to see if M-PE leads to better mental health and substance use outcomes and lower dropout rates. Participants will: * Attend multiple therapy sessions per week (M-PE) or receive usual care * Complete assessments at baseline, during treatment, end-of-treatment, 1-month, 3-month, and 6-month follow-up * Share feedback through surveys and interviews about their experience in the program

Posttraumatic Stress Disorder (PTSD)Substance Use Disorders (SUD)Comorbidity+1 more

Rutgers, The State University of New Jersey168 participantsStarted Sep 2025

Jacksonville, Florida, United States

COMPLETEDNA

Effect of tDCS Timing on Safety Memory in PTSD

NCT04152772

The primary purpose of this study is to investigate the effects of tDCS timing on extinction memory in PTSD. A total of 90 participants will be randomized equally across one of three groups: 1. One group receiving active stimulation during extinction followed by sham stimulation during consolidation 2. One group receiving sham stimulation during extinction followed by active stimulation during consolidation 3. One group receiving sham stimulation both during extinction and consolidation This study also includes an online sub-study (Aim 2) focused on contextual processing along the PTSD spectrum. The online study tests if there is an association between threat and non-threat learning in contextual and non-contextual situations. A maximum of 500 participants will be recruited using an online, panel-based platform.

PTSD

Butler Hospital62 participantsStarted Nov 2019

Providence, Rhode Island, United States

Project COMET: Massed Prolonged Exposure for PTSD and SUD

Effect of tDCS Timing on Safety Memory in PTSD

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