Osteoporosis Clinical Trials

Showing 221-240 of 353 trials

MAP-Calcification: MicroRNAs as Potential Biomarkers for Coronary Artery Calcification

NCT01992848

Coronary artery disease (CAD) remains the leading cause of mortality in the UK with an estimated 80,000 fatalities in 2010. Coronary artery calcification (CAC) is associated with atherosclerotic plaque burden and cardiovascular mortality. Mechanisms underlying isolated CAC have not been as yet been fully explained. MicroRNAs (miRNAs), known to act as regulators of gene expression, have also emerged as powerful biomarkers in the diagnosis and prognosis of cardiovascular disorders and may be used in the detection of CAC. We aim to investigate the potential for a "microRNA-signature" in patients with CAC by performing a prospective, case-controlled study to identify pathways associated with CAC in humans. Previous research has demonstrated an inverse relationship between CAC and bone mineral density (BMD), suggesting that these processes may be linked. In a further substudy we plan to define the relationship between CAC and BMD as well as a number of markers of bone metabolism.

Coronary Artery CalcificationCoronary Artery DiseaseOsteoporosis+1 more

University of Surrey45 participantsStarted Nov 2013

Guildford, Surrey, United Kingdom • Guildford, Surrey, United Kingdom

TERMINATEDNA

Bone Physiology & Mechanics in Osteomyoplasty Amputation Rehabilitation

NCT00271362

The purpose of the study is to compare the effect of different lower limb amputation surgical procedures on leg bone integrity and rehabilitation outcome.

AmputationFractureInflammation+1 more

VA Office of Research and Development95 participantsStarted Jan 2006

Oklahoma City, Oklahoma, United States

MAP-Calcification: MicroRNAs as Potential Biomarkers for Coronary Artery Calcification

Bone Physiology & Mechanics in Osteomyoplasty Amputation Rehabilitation

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