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Clinical Trials MelanomaTennessee

Melanoma Clinical Trials in Tennessee

Find 343 clinical trials for melanoma near Tennessee. Connect with research centers in your area.

All Melanoma trials nationwide All trials in Tennessee

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Status

RecruitingNot yet recruitingActive, not recruitingEnrolling by invitationCompletedTerminated

Phase

Early phase 1Phase 1Phase 1–2Phase 2Phase 2–3Phase 3Phase 4Not applicable

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Showing 141-160 of 343 trials

Active not recruitingA Phase 1-2 Study of ST101 in Patients With Advanced Solid TumorsThis is an open-label, two-part, phase 1-2 dose-finding study designed to determine the safety, tolerability, PK, PD, and proof-of-concept efficacy of ST101 administered IV in…NCT04478279·San Francisco, California and 10 others Active not recruitingA Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced MelanomaThis is a Phase 2, multicenter, open-label study of lifileucel (tumor-infiltrating lymphocytes \[TIL\]) in participants with previously treated advanced melanomaNCT07288203·Nashville, Tennessee and 4 others CompletedTrial of Dacarbazine With or Without Genasense in Advanced MelanomaThis study is being performed to prospectively determine whether dacarbazine plus Genasense is significantly better than dacarbazine plus placebo in chemotherapy-naive patients…NCT00518895·Mobile, Alabama and 76 others

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Data from ClinicalTrials.govTerms

CompletedStudy of Everolimus With Paclitaxel and Carboplatin in Patients With Metastatic MelanomaBased on data demonstrating synergy between paclitaxel and mammalian target of rapamycin (mTOR) inhibition, the investigators propose that the addition of everolimus to paclitaxel…NCT01014351·Fort Myers, Florida and 11 others

RecruitingA Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid TumorsThis is an open label, multicenter, phase 1/2 study to assess the safety/tolerability and preliminary clinical activity of STAR0602 as a single agent and in combination with…NCT05592626·Sacramento, California and 18 others

TerminatedGamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV MelanomaThis phase II trial is studying how well gamma-secretase/Notch signalling pathway inhibitor RO4929097 works in treating patients with stage IV melanoma.NCT01120275·Mobile, Alabama and 177 others

CompletedCarboplatin and Paclitaxel With or Without Sorafenib Tosylate in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by SurgeryThis randomized phase III trial studies carboplatin, paclitaxel, and sorafenib tosylate to see how well they work compared to carboplatin and paclitaxel in treating patients with…NCT00110019·Birmingham, Alabama and 218 others

CompletedA Study Comparing Trametinib and Dabrafenib Combination Therapy to Dabrafenib Monotherapy in Subjects With BRAF-mutant MelanomaThis was a two-arm, double-blinded, randomized, Phase III study comparing dabrafenib and trametinib combination therapy to dabrafenib administered with a placebo (dabrafenib…NCT01584648·Scottsdale, Arizona and 120 others

CompletedSRK-181 Alone or in Combination With Anti-PD-(L)1 Antibody Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (DRAGON)This was a multi-center, open-label, Phase 1, first-in-human (FIH), dose-escalation, and dose expansion study to evaluate the safety, tolerability, pharmacokinetics (PK)…NCT04291079·Fullerton, California and 21 others

CompletedMulticenter Selective Lymphadenectomy Trial II (MSLT-II)Subjects must be diagnosed with melanoma. All subjects receive sentinel lymphadenectomy.NCT00297895·San Diego, California and 62 others

CompletedGSK1120212 vs Chemotherapy in Advanced or Metastatic BRAF V600E/K Mutation-positive MelanomaThis is a two-arm, open-label, randomized Phase III study comparing single agent GSK1120212 to chemotherapy (either dacarbazine or paclitaxel) in subjects with Stage IIIc or Stage…NCT01245062·Tucson, Arizona and 111 others

CompletedA Study of Autogene Cevumeran (RO7198457) as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic TumorsThis is a Phase 1a/1b, open-label, multicenter, global, dose-escalation study designed to evaluate the safety, tolerability, immune response, and pharmacokinetics of autogene…NCT03289962·Scottsdale, Arizona and 32 others

TerminatedStudy Of Zelboraf (Vemurafenib) in Patients With Locally-Advanced, Unresectable, Stage IIIc Or Metastatic Melanoma and Activating Exon 15 BRAF Mutations Other Than V600EThis is an open-label, multicenter, single-agent, phase II study of continuous oral Zelboraf (vemurafenib) in participants with locally-advanced, unresectable, stage IIIc or…NCT01586195·Tucson, Arizona and 14 others

TerminatedNiraparib in the Treatment of Patients With Advanced PALB2 Mutated TumorsThe purpose of this study is to further evaluate the efficacy and safety of niraparib in patients with locally advanced or metastatic solid tumors and a pathogenic or likely…NCT05169437·Yuma, Arizona and 79 others

CompletedElectronic Brachytherapy for the Treatment of NMSCThe objective of this study is to record recurrence in patients treated for nonmelanoma (basal cell and squamous cell carcinomas) skin cancer using the Xoft Axxent Electronic…NCT01016899·Tuscaloosa, Alabama and 4 others

CompletedStudy Comparing the Efficacy of MEK162 Versus Dacarbazine in Unresectable or Metastatic NRAS Mutation-positive MelanomaTwo-arm, randomized, prospective, open-label, multi-center, phase III study to compare the efficacy and safety of MEK162 (45 mg BID) versus dacarbazine (1000 mg/m2 IV every 3…NCT01763164·Fayetteville, Arkansas and 228 others

Active not recruitingIpilimumab With or Without Sargramostim in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by SurgeryThis randomized phase II trial is studying how well giving ipilimumab with or without sargramostim (GM-CSF) works in treating patients with stage III or stage IV melanoma that…NCT01134614·Birmingham, Alabama and 256 others

CompletedSubstudy 02B: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With First Line (1L) Advanced Melanoma (MK-3475-02B/KEYMAKER-U02)Substudy 02B is part of a larger research study where researchers are looking for new ways to treat advanced melanoma that has not been treated before.NCT04305054·Los Angeles, California and 59 others

CompletedPretreatment Anti-Therapeutic Antibodies (PATA) in Patients Treated With hu14.18K322A AntibodyHu14.18K322A is a monoclonal antibody developed at St. Jude Children's Research Hospital (SJCRH) that is made to bind to cancer cells that have a molecule called GD2 on their…NCT02159443·Memphis, Tennessee

RecruitingComparing the Effectiveness of Less Invasive Procedures With the Current Standard of Care for the Treatment of Older Adults With Early-Stage MelanomaThis phase III trial compares the effect of wide local excision (WLE) alone to usual care with WLE plus sentinel lymph node (SLN) biopsy for the treatment of older adults with…NCT07068074·Birmingham, Alabama and 180 others

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Other Conditions in Tennessee

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