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Clareo Health | Melanoma Clinical Trials in Pennsylvania | 457 Studies

Clinical Trials MelanomaPennsylvania

Melanoma Clinical Trials in Pennsylvania

Find 457 clinical trials for melanoma near Pennsylvania. Connect with research centers in your area.

All Melanoma trials nationwide All trials in Pennsylvania

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RecruitingNot yet recruitingActive, not recruitingEnrolling by invitationCompletedTerminated

Phase

Early phase 1Phase 1Phase 1–2Phase 2Phase 2–3Phase 3Phase 4No phase

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Showing 361-380 of 457 trials

RecruitingTegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid TumorsThis phase I/II trial evaluates the highest safe dose, side effects, and possible benefits of tegavivint in treating patients with solid tumors that has come back (recurrent) or…NCT04851119·Birmingham, Alabama and 20 others

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Data from ClinicalTrials.govTerms

CompletedEverolimus in Treating Patients With Stage IV MelanomaRATIONALE: Drugs used in chemotherapy, such as everolimus, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.NCT00098553·Scottsdale, Arizona and 93 others

CompletedSargramostim, Vaccine Therapy, or Sargramostim and Vaccine Therapy in Preventing Disease Recurrence in Patients With Melanoma That Has Been Removed By SurgeryThis randomized phase III trial studies sargramostim or vaccine therapy alone to see how well they work compared to sargramostim and vaccine therapy together in preventing disease…NCT01989572·Birmingham, Alabama and 147 others

Active not recruitingNBTXR3 Activated by Radiotherapy for Patients With Advanced Cancers Treated With An Anti-PD-1 TherapyThe 1100 study is an open-label, Phase I, dose escalation and expansion prospective clinical study to assess the safety of intratumoral injection of NBTXR3 activated by…NCT03589339·San Francisco, California and 12 others

RecruitingA Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid TumorsThis is a Phase 1/2a, open-label, study to evaluate the safety and preliminary efficacy of intratumoral T3011 given alone and in combination with intravenous pembrolizumab in…NCT04370587·Gilbert, Arizona and 8 others

RecruitingStudy to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.This is a Phase 3, multicenter, open-label, randomized, parallel group, treatment study to assess the efficacy and safety of lifileucel in combination with pembrolizumab compared…NCT05727904·Birmingham, Alabama and 81 others

TerminatedTissue Procurement Substudy for Participants in Study CP-MGA271-01The purpose of this study is to gain a better understanding about how the study drug MGA271 works. No test drug will be given in this study.NCT01918930·Los Angeles, California and 6 others

CompletedA Phase I Trial of Vemurafenib and Hydroxychloroquine in Patients With Advanced BRAF Mutant MelanomaThis is a Phase I study combining vemurafenib and hydroxychloroquine in the treatment of BRAF V600E+ metastatic melanoma.NCT01897116·Philadelphia, Pennsylvania

UnknownSafety, Tolerability and Pharmacokinetics of a Monoclonal Antibody Specific to B-and T-Lymphocyte Attenuator (BTLA) as Monotherapy and in Combination With an Anti-PD1 Monoclonal Antibody for Injection in Subjects With Advanced MalignanciesThe primary objective is to assess the safety and tolerability of TAB004 as monotherapy and in combination with toripalimab in subjects with selected advanced solid malignancies…NCT04137900·Birmingham, Alabama and 23 others

CompletedEfficacy and Safety Study of Talimogene Laherparepvec Compared to Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) in MelanomaThe objective of this study is to evaluate the efficacy and safety of treatment with talimogene laherparepvec compared to subcutaneously administered GM-CSF in patients with…NCT00769704·Tucson, Arizona and 82 others

CompletedA Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function MutationsThis study employs a 2-stage design that aims to evaluate the efficacy and safety of ENV- 101, a potent Hedgehog (Hh) pathway inhibitor, in patients with refractory advanced solid…NCT05199584·Los Angeles, California and 15 others

CompletedPattern of Use and Safety/Effectiveness of Nivolumab in Routine Oncology PracticeThis is an observational, multicenter study in participants treated with nivolumab for the approved indications of melanoma and Lung cancer in Australia, the EU, Switzerland, the…NCT02847728·Palm Springs, California and 93 others

CompletedIpilimumab With or Without High-Dose Recombinant Interferon Alfa-2b in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by SurgeryThis randomized phase II trial studies how well ipilimumab with or without high-dose recombinant interferon alpha-2b works in treating patients with stage III-IV melanoma that…NCT01708941·Birmingham, Alabama and 275 others

RecruitingSafety and Efficacy of OBX-115 in Advanced Solid TumorsThis is a study to investigate the safety and efficacy of an investigational OBX-115 regimen in adult participants with advanced solid tumors.NCT06060613·Los Angeles, California and 9 others

Active not recruitingA Study of Relatlimab Plus Nivolumab Versus Nivolumab Alone in Participants With Advanced MelanomaThe purpose of this study is to determine whether relatlimab in combination with nivolumab is more effective than nivolumab monotherapy in treating unresectable melanoma or…NCT03470922·Tucson, Arizona and 126 others

CompletedCirculating Tumor Material in Colorectal Cancer and MelanomaObservational study to allow the collection of blood and medical information to evaluate the role of circulating tumor material in patients with colorectal cancer and melanomaNCT02907086·Philadelphia, Pennsylvania

CompletedDabrafenib With Trametinib in the Adjuvant Treatment of High-risk BRAF V600 Mutation-positive Melanoma (COMBI-AD).This was a two-arm, randomized, double-blind Phase III study of dabrafenib in combination with trametinib versus 2 placebos in the adjuvant treatment of melanoma after surgical…NCT01682083·Birmingham, Alabama and 167 others

TerminatedTovorafenib (DAY101) or in Combination With Pimasertib for Participants With Melanoma and Other Solid TumorsThis is a subprotocol of Master Protocol DAY101-102 and is a Phase 1b/2, multi-center, open label subprotocol of participants ≥12 years of age, with recurrent or progressive solid…NCT07121829·Los Angeles, California and 9 others

RecruitingA Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain MetastasesThis phase II trial compares the effect of encorafenib, binimetinib, and nivolumab versus ipilimumab and nivolumab in treating patients with BRAF- V600 mutant melanoma that has…NCT04511013·Birmingham, Alabama and 330 others

TerminatedA Study of Varlilumab (Anti-CD27) and Ipilimumab and CDX-1401 in Patients With Unresectable Stage III or IV MelanomaThis is a study to determine the clinical benefit (how well the drug works), safety and tolerability of combining a) varlilumab and ipilimumab and b) varlilumab, ipilimumab…NCT02413827·San Francisco, California and 7 others

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