Liver Disease Clinical Trials

Showing 281-300 of 1,498 trials

Endoscopic Ultrasound-guided Measurement of Portal Vein Pressure Gradient

NCT07062289

This study aims to evaluate the accuracy and safety of a novel endoscopic ultrasound-guided portal pressure gradient (EUS-PPG) measurement technique in 42 adults with liver cirrhosis and portal vein thrombosis (blood clots in the liver's main vein), a condition where current standard testing (HVPG) fails to provide reliable pressure readings. Participants will undergo both EUS-PPG (using a specialized needle under ultrasound guidance) and HVPG procedures to compare results; EUS-PPG will be performed under general anesthesia in a left-side lying position-an innovative approach-while also enabling immediate endoscopic treatment of bleeding veins if detected during the same session. The primary goals are to validate EUS-PPG's safety in this high-risk group, establish its correlation with HVPG, and pioneer an integrated diagnosis-treatment protocol to reduce hospital stays and costs. The study runs from July 2025 to June 2027 at Zhejiang University School of Medicine.

Portal Vein ThrombosisPortal Hypertension Related to Cirrhosis

Zhejiang University42 participantsStarted Jul 2025

COMPLETEDPhase 2

Benefits of Trimetazidine in MASLD Patients

NCT06140953

Objective of this study is to determine the clinical benefits of trimetazidine in improvement of MASLD

Metabolic Associated Fatty Liver Disease

October 6 University60 participantsStarted Dec 2023

Banī Suwayf, Beni Suweif Governorate, Egypt

Endoscopic Ultrasound-guided Measurement of Portal Vein Pressure Gradient

Benefits of Trimetazidine in MASLD Patients

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