Leukemia Clinical Trials

Showing 5821-5840 of 10,987 trials

Oral Immunotherapy for Desensitization in Children, Adolescents, and Young Adults With Hen Egg Allergy

NCT04056299

To determine the efficacy and safety of AR201 in a characterized oral desensitization immunotherapy (CODIT™) regimen in hen egg-allergic subjects aged 4 to 26 years, inclusive.

Hen Egg Allergy

Aimmune Therapeutics, Inc.15 participantsStarted Aug 2019

Little Rock, Arkansas, United States • Rolling Hills Estates, California, United States • San Diego, California, United States +8 more locations

TERMINATEDPhase 1

IMRT-TMI With Fludarabine as Myeloablative Conditioning for Allogeneic HSCT

NCT03696537

This is a phase I/II clinical trial on the use of total marrow irradiation (TMI) given concurrently with fludarabine, a chemotherapy drug commonly used to treat leukemia, as a myeloablative therapy for patients undergoing Allo-HSCT. TMI is a targeted technique to deliver radiation to the bone marrow while minimizing dose to other normal organs in the body. In phase I of the clinical study, the dose of radiation to the bone marrow will be incrementally increased to determine the highest tolerated TMI dose. In phase II, the effectiveness of the TMI-fludarabine conditioning regimen utilizing that dose of radiation will be studied. Acute and long-term toxicity data as well as quality of life data will also be studied. \*Stopping criteria was met during the first dose level cohort in Phase l. The trial will not continue into Phase II as originally planned.

Acute Myeloid LeukemiaChronic Myeloid LeukemiaAcute Lymphocytic Leukemia+1 more

Naoyuki G. Saito, M.D., Ph.D.6 participantsStarted Aug 2018

Indianapolis, Indiana, United States

Oral Immunotherapy for Desensitization in Children, Adolescents, and Young Adults With Hen Egg Allergy

IMRT-TMI With Fludarabine as Myeloablative Conditioning for Allogeneic HSCT

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