Leukemia Clinical Trials

Showing 5321-5340 of 10,987 trials

Clinical Study of TBF Regimen in Allo-HSCT in Patients With CNS Leukemia

NCT05667402

Central nervous system (CNS) leukemia is a poor prognostic factor for allogeneic hematopoietic stem cell transplantation (allo-HSCT). Thiotepa can penetrate the blood-brain barrier and has immunosuppressive effects and similar effects to irradiation in allo-HSCT. This project aims to investigate whether the TBF regimen is superior to the traditional modified BuCY2 regimen to improve the long-term survival of the CNS leukemia patients.

Central Nervous System LeukemiaAllogeneic Hematopoietic Stem Cell Transplantation

First Affiliated Hospital Xi'an Jiaotong University50 participantsStarted Jan 2023

Xi'an, Shaanxi, China

TERMINATEDPhase 1

Ceritinib + Trametinib in Patients With Advanced ALK-Positive Non-Small Cell Lung Cancer (NSCLC)

NCT03087448

This is a phase I/II study of ceritinib and trametinib in Stage IIIB or IV anaplastic lymphoma kinase (ALK) rearranged non-small cell lung cancer (NSCLC). The Phase I portion will investigate the safety and tolerability of the combination of ceritinib and trametinib in ALK or ROS-1 rearranged NSCLC. The Phase II portion will investigate the clinical efficiency of the combination of ceritinib and trametinib in 3 single arm cohorts: ALKi (ALK inhibitor) naïve patients; post-crizotinib progressed disease (PD) patients; and PD second line ALK tyrosine kinase inhibitor (TKI) patients.

Non-small Cell Lung Cancer

University of California, San Francisco9 participantsStarted Sep 2017

Davis, California, United States • San Francisco, California, United States

Clinical Study of TBF Regimen in Allo-HSCT in Patients With CNS Leukemia

Ceritinib + Trametinib in Patients With Advanced ALK-Positive Non-Small Cell Lung Cancer (NSCLC)

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