Leukemia Clinical Trials

Showing 5341-5360 of 10,987 trials

Azacitidine Combined With Venetoclax and ATRA in Newly Diagnosed AML

NCT05654194

This is a single arm study to evaluate the safety and efficiency of azacitidine (AZA) combination with venetoclax and ATRA in Patients With Newly diagnosed acute myeloid leukemia. Azacitidine, venetoclax and ATRA, may stop the growth of cancer cells, either by demethylation, by promoting cells differentiation or by killing the cells.

Acute Myeloid Leukemia

The First Affiliated Hospital of Soochow University30 participantsStarted Oct 2022

Suzhou, China

COMPLETED

Microcirculation in Spontaneous Breathing Trial

NCT04711590

Weaning ventilator support in critically ill patients is crucial. Both delayed extubation and unexpected early reintubation are harmful to the patients. Weaning parameters and spontaneous breathing trial are used to investigate the indication and predict the successful extubation. Hemodynamic stability and physical reserve are important indicators as well. Microcirculation parameters are known to be more sensitive to the change of hemodynamic status than macrocirculation parameters. We hypothesize that the change of sublingual microcirculation before and after spontaneous breathing trial is different between the the patients with successful extubation and the patients with failed extubation. Thus, this study measures sublingual microcirculation in patients receiving spontaneous breathing trial and record the extubation status (successful or failed). The microcirculation parameters before and after spontaneous breathing trial are compared between the the patients with successful extubation and the patients with failed extubation.

Critically Ill

National Taiwan University Hospital59 participantsStarted Dec 2019

Taipei, Taiwan

Azacitidine Combined With Venetoclax and ATRA in Newly Diagnosed AML

Microcirculation in Spontaneous Breathing Trial

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