Kidney Disease Clinical Trials

Showing 2241-2260 of 3,902 trials

Individualized Treatment Strategy for Patients With Metastatic Non-clear Cell Renal Cell Carcinoma

NCT04644432

The purpose of the open-label INDIGO-study is to examine whether a first line individualized treatment strategy based on DNA and RNA analyses from the patient's tumor is feasible. Moreover, to involve the patient further in their treatment via patient-reported outcomes (PRO) measurements in a value-based healthcare setup with simultaneous analyses of the financial costs of this strategy. The patients are assigned into 4 treatment arms according to the results of their DNA and RNA analyses. All patients receive electronic questionnaires regarding symptoms and side effects weekly and questionnaires regarding quality of life monthly. Based on each patient's answers of the questionnaires the patient receives advices in the app to reduce the symptoms and side effects or the patient is instructed to contact the hospital. The hypothesis: Basing the choice of first-line treatment for DNA mutations and RNA profiles in a heterogeneous patient population increases the overall response rate for the total population to 30% compared to 10% for historical cohorts.

Metastatic Renal Cell CarcinomaKidney NeoplasmUrologic Neoplasms+1 more

Herlev and Gentofte Hospital30 participantsStarted Mar 2020

Herlev, Denmark

COMPLETEDPhase 2/3

Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency

NCT00915343

This is a randomised, controlled, open, two-armed, two-period cross-over, multi-centre phase II/III study to assess the safety, tolerability and pharmacokinetics of once-daily oral modified-release hydrocortisone in comparison to conventional thrice-daily oral hydrocortisone tablets in patients with adrenal insufficiency

Adrenal Insufficiency

Shire64 participantsStarted Aug 2007

Individualized Treatment Strategy for Patients With Metastatic Non-clear Cell Renal Cell Carcinoma

Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency

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