Heart Disease Clinical Trials in Boston

Showing 81-100 of 535 trials

Imaging Histone Deacetylase in the Heart

NCT03549559

The overall goal of this PET-MR imaging trial is to evaluate 11C-Martinostat, a histone deacetylase targeted radioligand, in patients with aortic stenosis, individuals with diabetes, and healthy volunteers.

Heart Failure With Normal Ejection FractionLeft Ventricular HypertrophyAortic Valve Stenosis+1 more

Massachusetts General Hospital96 participantsStarted Sep 2018

Boston, Massachusetts, United States

TERMINATEDNA< 1 mile

Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients

NCT03202641

The goal of this interventional crossover study, in intubated and mechanically ventilated Acute Respiratory Distress Syndrome (ARDS) patients, is to compare two positive end-expiratory pressure (PEEP) titration techniques regarding: respiratory mechanics, gas exchange, changes in aeration, ventilation/perfusion matching its impact on cardiac function, especially the right heart (RH). The PEEP titration techniques are: PEEP selection based on low PEEP/high FiO2 table ("PEEPARDSnet") and lung recruitment maneuver (LRM) plus PEEPdec titration based on the best compliance of the respiratory system("PEEPLRM").

ARDS, HumanLung Injury, AcuteRespiratory Distress Syndrome+4 more

Massachusetts General Hospital2 participantsStarted Jun 2019

Boston, Massachusetts, United States

RECRUITINGNA< 1 mile

Pulmonary Artery DenerVation Clinical Study Using the Gradient Denervation System in Heart Failure Patients With Pulmonary Hypertension Group 2 (PreVail-PH2 Study)

NCT06052072

This early feasibility study is intended to characterize the impact of pulmonary artery denervation on the quality of life in Heart Failure Patients with Group 2 Pulmonary Hypertension

Group 2 Pulmonary HypertensionHeart Failure

Gradient Denervation Technologies50 participantsStarted Feb 2024

Chicago, Illinois, United States • Boston, Massachusetts, United States • Durham, North Carolina, United States +5 more locations

Imaging Histone Deacetylase in the Heart

Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients

Pulmonary Artery DenerVation Clinical Study Using the Gradient Denervation System in Heart Failure Patients With Pulmonary Hypertension Group 2 (PreVail-PH2 Study)

Heart Disease Trials in Other Cities

Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

A Randomized Trial Assessing the Effects of Inclisiran on Clinical Outcomes Among People With Cardiovascular Disease

A Extension Study of Udenafil in Adolescents

Effects of Prolonged Delivery of Nitric Oxide Gas on Plasma Reduction-Oxidation Reactions in Cardiac Surgical Patients

MIcrovascular dysfuNction In Moderate-severe Psoriasis

A SkeleTal Muscle Recovery Intervention With Dietary Protein in Heart Failure

Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy

Plasma ExtrAcellular RNAs and Biomarkers of Heart FaiLure During Decongestion: PEARL-HF Study

EVOC - EVs in Obesity and Cardiometabolic Disease

Diffusion MRI in Heart Failure

Supporting Health in Veterans With Heart Failure

SyncAV Post-Market Trial

Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)

A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)

Research Study to Look at How Well Semaglutide Works in People Living With Heart Failure, Obesity and Type 2 Diabetes

A Study to Assess Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Reduced Ejection Fraction (Cycle-1-REF)

Albumin Utilization in Adult Cardiac Surgical Patients: Retrospective

Other Conditions in Boston