Colorectal Cancer Clinical Trials in Pittsburgh

Showing 21-40 of 169 trials

A Study to Test DSP107 in Combination With Atezolizumab in Comparison With Fruquintinib as a New Treatment for Colorectal Cancer.

NCT07235293

This clinical study is testing whether a new combination of medicines (DSP107 and atezolizumab) is more effective and safer than an existing treatment (fruquintinib) for people with advanced colorectal cancer that is microsatellite stable (MSS). Participants will be randomly assigned to receive one of the two treatments, and researchers will monitor how well the cancer responds, how safe the treatments are, and how the body processes them. The study hopes to show that the new combination can improve outcomes for patients with this type of colorectal cancer.

Colorectal Cancer

Kahr Bio Australia Pty Ltd90 participantsStarted Jan 2026

Aurora, Colorado, United States • Florida City, Florida, United States • Durham, North Carolina, United States +13 more locations

ACTIVE_NOT_RECRUITINGPHASE2/PHASE3< 1 mile

Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer

NCT04137107

This phase II/III trial studies the best dose of duloxetine and how well it works in preventing pain, tingling, and numbness (peripheral neuropathy) caused by treatment with oxaliplatin in patients with stage II-III colorectal cancer. Duloxetine increases the amount of certain chemicals in the brain that help relieve depression and pain. Giving duloxetine in patients undergoing treatment with oxaliplatin for colorectal cancer may help prevent peripheral neuropathy.

Stage II Colorectal Cancer AJCC v8Stage III Colorectal Cancer AJCC v8

Alliance for Clinical Trials in Oncology220 participantsStarted Jun 2020

Birmingham, Alabama, United States • Mobile, Alabama, United States • Anchorage, Alaska, United States +790 more locations

A Study to Test DSP107 in Combination With Atezolizumab in Comparison With Fruquintinib as a New Treatment for Colorectal Cancer.

Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer

Colorectal Cancer Trials in Other Cities

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

A Phase 1 in Patients With HLA-A*0201+ and WT1+ Recurrent/Metastatic Cancers

Prevention of Colorectal Cancer Through Multiomics Blood Testing

A Phase 1/1b Study of IAM1363 in HER2 Cancers

A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer

Study of Onvansertib in Combination With FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab Versus FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer in Adult Participants With a KRAS or NRAS Mutation

A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)

BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours

EXoPERT EMERALD Clinical Study

Genetic Analysis of Blood and Tissue Samples From Patients With Advanced Cancer, Moonshot Study

Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors

Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors

Phase 1/2a Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of WEF-001 as Monotherapy in Advanced KRAS-Mutant Solid Tumours.

Gevokizumab With Standard of Care Anti-cancer Therapies for Metastatic Colorectal, Gastroesophageal, and Renal Cancers

A Study of Select Drug Combinations in Adult Patients With Advanced/Metastatic BRAF V600 Colorectal Cancer

The PharmFIT Study

A Study of MGC026 in Participants With Advanced Solid Tumors

Other Conditions in Pittsburgh