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To determine the pharmacokinetics of the combination. III. To evaluate the selected biomarkers of drug effect in patients with advanced solid tumors or refractory metastatic colorectal cancer (CRC). IV. Evaluate the activity of the combination in terms of objective response rate (per Response Evaluation Criteria in Solid Tumors \[RECIST\] 1.1), progression-free survival (PFS). OUTLINE: This is a phase I, dose-escalation study of selumetinib followed by a phase Ib study. Patients receive selumetinib orally (PO) twice daily (BID) on day -7 of course 1 and then on days 1-28 (one dose on day 1 only). Patients also receive cyclosporine PO BID on day -3 of course 1 and then on days 1-28 (one dose on day 1 only). Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up for 30 days.2d:T1afb,Inclusion Criteria: * Before any study procedures are performed, subjects will have the details of the study described to them, and they will be given a written informed consent document to read; then, if subjects consent to participate in the study, they will indicate that consent by signing and dating the informed consent document in the presence of study personnel * DOSE ESCALATION PHASE: Histological or cytopathological diagnosis of an advanced cancer that is refractory to standard therapy or for which no standard therapy exists * COHORT EXPANSION PHASE: Histological or cytopathological diagnosis of advanced/metastatic unresectable colorectal cancer with known rat sarcoma viral oncogene homolog (RAS) mutational status; patients with known B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutations will not be eligible for the expansion cohort; all patients must have received and progressed or be intolerant of an oxaliplatin-containing regimen and an irinotecan-containing regimen * COHORT EXPANSION PHASE: At least one tumor lesion amenable to core needle biopsy without unacceptable risk of a major procedural complication (one pretreatment and at least one on-treatment biopsy will be performed) * COHORT EXPANSION PHASE: Patient must have measurable lesions as defined by RECIST version 1.1 criteria * Eastern Cooperative Oncology Group (ECOG) performance status 0-1 * Estimated life expectancy \> 3 months * Absolute neutrophil count (ANC) \>= 1,500/mcl * Platelets \>= 100,000/mcl * Hemoglobin \>= 9 g/dl * Estimated glomerular filtration rate (eGFR) greater than or equal to 60 ml/min/1.73 m\^2 * Serum total bilirubin \< 1.5 x upper limit or normal (ULN) * Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase \[SGOT\]), alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 2.5 x ULN; if liver involvement, AST, ALT =\< 5.0 x ULN * Alkaline phosphatase =\< 2.5 x ULN; if liver involvement, alkaline phosphatase =\< 5.0 x ULN * Serum albumin \>= 2.5 g/dl * International normalized ratio (INR) =\< 1.5 x ULN or prothrombin time (PT) =\< 1.5 x ULN seconds above control unless patient is currently receiving warfarin therapy for the treatment or prevention of venous thrombosis * A male subject of fathering potential must use an adequate method of contraception to avoid conception throughout the study (and for up to 12 weeks after the last dose of study drug) to minimize the risk of pregnancy; if the partner is pregnant or breastfeeding, the subject must use a condom * Women of childbearing potential (WOCBP) must be using an adequate method of contraception to avoid pregnancy throughout the study and for up to 12 weeks after the last dose of study drug to minimize the risk of pregnancy; WOCBP must have a negative serum or urine pregnancy test within 72 hours before the start of the investigational product * Ability to understand and the willingness to sign a written informed consent document Exclusion Criteria: * Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier * Patients who are receiving any other investigational agents * Prior full field radiotherapy \< 4 weeks or limited field radiotherapy \< 2 weeks prior to first study drug administration * Patients with brain metastases may participate in this trial provided they are clinically stable; patients who are \< 1 month from definitive therapy, receiving steroid therapy or taper, or anti-convulsant medications (started for brain metastases) must not be included * History of allergic reactions attributed to compounds of similar chemical or biologic composition to AZD6244 or cyclosporine A or their excipients * Patients with a history of thrombotic or embolic events within the last six months such as a cerebrovascular accident (including transient ischemic attacks), pulmonary embolism * Cardiac conditions as follows: * Active coronary artery disease, unstable or newly diagnosed angina or myocardial infarction less than 12 months prior to first study drug administration * Class II-IV New York Heart Association (NYHA) congestive heart failure * Uncontrolled hypertension (systolic blood pressure \[BP\] \> 150 mmHg and diastolic BP \> 90 mmHg for 24 hours) despite optimal medical management; blood pressure must be below 140/90 mmHg at screening; subjects with a history of hypertension who are receiving treatment with calcium channel blockers that are cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) substrates should be changed to an alternative antihypertensive medication prior to first study drug administration * Cardiac arrhythmias requiring anti-arrhythmic therapy other than beta blockers or digoxin * Corrected QT (QTc) (Frederica) prolongation \> 480 msec * Subjects with valvular heart disease Common Terminology Criteria for Adverse Events (CTCAE) (version 4.0) grade 2 * Known left ventricular ejection fraction (LVEF) \< 50% * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris (Canadian Cardiovascular Society grade II-IV despite medical therapy), cardiac arrhythmia, active bleeding diatheses, or psychiatric illness/social situations that would limit compliance with study requirements * Known ophthalmological conditions as follows: intra-ocular pressure \> 21 mmHg, or uncontrolled glaucoma (irrespective of intra-ocular pressure); current or past history of central serous retinopathy or retinal vein occlusion * Major surgical procedure, open biopsy, or significant traumatic injury less than 3 weeks or those who receive minor surgical procedures (eg core biopsy or fine needle aspiration) within 1 week from first dose of first study drug administration * Known inability to swallow capsules * Known history of human immunodeficiency virus (HIV), hepatitis B, and/or hepatitis C (no additional laboratory tests for HIV, hepatitis \[Hep\] B, or Hep C are required for screening) * Inability to comply with study and/or follow-up procedures * Pregnant women are excluded from this study; breastfeeding should be discontinued if the mother is treated with AZD6244 * Patients with hyponatremia (sodium \< 130 mmol/L) * Baseline serum potassium \< 3.5 mmol/L (potassium supplementation may be given to restore the serum potassium above this level prior to study entry) * Baseline serum calcium \< 8.4 mg/dL (calcium supplementation may be given to restore the serum calcium above this level prior to study entry) * Prisoners or subjects who are involuntarily incarcerated * Patients who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness28:["$","$L2b",null,{"trial":{"nctId":"NCT02188264","briefTitle":"Selumetinib and Cyclosporine in Treating Patients With Advanced Solid Tumors or Advanced or Metastatic Colorectal Cancer","officialTitle":"A Phase IB Study of the Combination of AZD6244 Hydrogen Sulfate (Selumetinib) and Cyclosporin A (CsA) in Patients With Advanced Solid Tumors With an Expansion Cohort in Metastatic Colorectal Cancer","briefSummary":"This phase I/Ib trial studies the side effects and best dose of selumetinib when given together with cyclosporine in treating patients with solid tumors or colorectal cancer that have spread to other places in the body and cannot be cured or controlled with treatment. Selumetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Biological therapies, such as cyclosporine, use substances made from living organisms that may stimulate or suppress the immune system in different ways and stop tumor cells from growing. 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The goal was to find the best dose and understand the safety of this combination treatment.","version":2,"mainIdea":"Finding the right dose and safety","studyAbout":"This clinical trial tested a combination of selumetinib and cyclosporine in patients with advanced solid tumors or metastatic colorectal cancer that could not be treated effectively with standard therapies. The goal was to find the best dose and understand the safety of this combination treatment.","comparedWith":null,"mayQualifyIf":["You have advanced solid tumors or metastatic colorectal cancer that hasn't responded to standard treatments.","Your cancer is not operable and you are looking for new treatment options.","You are interested in participating in a study to help researchers learn more about potential treatments."],"newTreatment":"Selumetinib","lessRelevantIf":["You have received chemotherapy or radiation therapy within the last month.","You have a history of certain heart conditions or uncontrolled high blood pressure.","You are currently pregnant or breastfeeding."],"questionsToAsk":["What are the potential side effects of selumetinib and cyclosporine?","How does this treatment compare to my current options?","What is the process for participating in this trial?","How often will I need to come in for treatment and monitoring?","What happens if I experience side effects during the trial?","How will my progress be monitored during the study?"],"careConversation":"This study may be relevant for patients with advanced solid tumors or colorectal cancer who have exhausted standard treatment options. It's important to discuss how this trial fits into your overall treatment plan, including potential side effects, the logistics of participation, and how it aligns with your personal health goals.","worthDiscussingIf":["You have advanced solid tumors or metastatic colorectal cancer that hasn't responded to standard treatments.","Your cancer is not operable and you are looking for new treatment options.","You are interested in participating in a study to help researchers learn more about potential treatments."],"likelyWontQualifyIf":["You have received chemotherapy or radiation therapy within the last month.","You have a history of certain heart conditions or uncontrolled high blood pressure.","You are currently pregnant or breastfeeding."],"participationBullets":["Participants will take selumetinib and cyclosporine orally twice a day.","There will be regular monitoring and tests to check for side effects and treatment effectiveness.","Participants will need to undergo biopsies to assess their tumors.","Follow-up will occur 30 days after completing the treatment."],"participationDetails":{"visitRhythm":"Every 28 days for treatment cycles","treatmentLength":"Until disease progression or unacceptable side effects occur","participationCycles":"Ongoing, with each cycle lasting 28 days"},"whatParticipatingInvolves":["Participants will take selumetinib and cyclosporine orally twice a day.","There will be regular monitoring and tests to check for side effects and treatment effectiveness.","Participants will need to undergo biopsies to assess their tumors.","Follow-up will occur 30 days after completing the treatment."]},"aiSummaryGeneratedAt":"$D2026-05-02T20:47:40.841Z","id":"03ece0cd-d3ea-4363-84eb-af60789e959d","createdAt":"$D2026-04-27T11:17:34.325Z","updatedAt":"$D2026-05-02T20:47:40.841Z"}}]

What this study is about