History or presence of central nervous system disease

Patients with a history of another primary cancer within 5 years

Prior chemotherapy for metastatic colorectal cancer

Prior full field radiotherapy within 4 weeks or limited field radiotherapy within 2 weeks before entry to study

Major surgery within 4 weeks or minor surgery within 2 weeks before entry to study

Investigational drugs within 4 weeks before entry to study

Prior therapy with anti-VEGF agents

Any prior therapy with oxaliplatin or allergy to platinum-containing drugs

Peripheral neuropathy with functional impairment

Female patients who are pregnant or breast feeding

Any severe or uncontrolled medical conditions which could prevent participation in study

Patients who are taking Coumadin

Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Metastatic Colorectal Cancer.