Moderate-to-Severe Dry Eye Disease Relief Using Acoltremon

Exclusion Criteria

• •History of corneal or conjunctival surgery
• •History of herpes zoster ophthalmicus, herpes simplex virus keratitis, or other viral corneal infection
• •History of neurotrophic keratitis
• •Prior significant facial trauma or sinus surgery
• •Mental or physical condition impairing ability to complete questionnaires
• •Use of Restasis®, Xiidra®, or Miebo within 30 days
• •Use of other topical anti-inflammatory medications within 30 days
• •Use of varenicline nasal spray within 30 days
• •Use of artificial tears within 2 hours prior to screening or during study period
• •Glaucoma requiring topical therapy
• •Contact lens or eyelid scrub use within 7 days
• •Punctal plugs within 14 days
• •Oxervate historical use
• •Amniotic membrane or Serum Tears historical use
• •History of Sjögren's disease
• •History of LASIK within 1 year