SPARC - Screening for Lung Cancer With Platelets Via an AI-enabled RNA-based Classifier

Exclusion Criteria

• •Other diagnosis of, or treatment for, any cancer within the last 6 months except for non-melanoma skin cancer, carcinoma in situ of the cervix, or low-grade prostate cancer (defined as Gleason score ≤ 6) treated locally
• •A history of lung cancer or metastatic cancer to the lungs from an extrathoracic primary site with definitive treatment (surgical, medical, or radiotherapy) within the past 2 years
• •Currently receiving any systemic therapy (chemotherapy, immunotherapy, and/or targeted therapy) or radiation therapy for lung cancer
• •Already undergone surgical resection of the lung cancer in part or in whole
• •Have undergone invasive diagnostic or therapeutic procedures (e.g., biopsy, surgery) related to the lung nodule within the past 3 months
• •Unable to provide blood sample
• •Study Population 2: Control Subjects
• •Any active malignancy or diagnosis of cancer within the last 6 months except for non-melanoma skin cancer, carcinoma in situ of the cervix, or low-grade prostate cancer (defined as Gleason score ≤ 6) treated locally
• •Treatment for any cancer within the last 6 months except for non-melanoma skin cancer, carcinoma in situ of the cervix, or low-grade prostate cancer (defined as Gleason score ≤ 6) treated locally
• •Hospitalization or surgery (other than minor surgery such as mole removal) within the last 8 weeks
• •Renal failure (defined as eGFR \< 60 mL/min/1.73m² or on dialysis)
• •Liver failure (defined as having hepatic encephalopathy of any degree, OR moderately severe coagulopathy defined as INR ≥ 1.5, OR known cirrhosis, OR ALT of ≥ 10X ULN, OR total bilirubin of ≥ 3.0 mg/dL, OR diagnosis of liver failure)
• •Decompensated or end-stage heart failure (defined as ACC/AHA Stage C or Stage D heart failure)
• •Venous thrombosis, myocardial infarction, or stroke within the last 8 weeks
• •Currently pregnant or have been pregnant within the last 12 weeks
• •Any blood product transfusion within the last 8 weeks
• •Personal history of lung cancer at any time
• •Unable to provide blood sample