Lead Sponsor

Yuvell

Collaborators

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

Yes

•1. 18 years or older at time of treatment.
•2. At least mild periorbital skin wrinkling, mild frown lines at maximum frown and mild.
•midface volume deficiency as assessed by the investigator
•3. Subject has a stable medical condition with no uncontrolled systemic disease.
•4. Willingness to participate in the routine follow-up after 8 weeks and 22 weeks and a signed informed consent form.
•5. Subject already visiting the clinic for the specific treatment.

•1. Pregnancy and breast feeding.
•2. Neuromuscular disease (e.g. myasthenia gravis, Eaton - Lambert syndrome).
•3. Known impairment of blood coagulation.
•4. Drooping eyelid.
•5. Known allergy to botulinum toxin or human albumin (blood protein).
•6. Presence of acute infection or inflammation at the proposed injection sites.
•7. Botulinum toxin treatment in the glabella within the last 16 weeks.
•8. HA- Filler treatment in the midface or periorbital area within the last 6 months.
•9. Patients with a history of autoimmune disease or who are receiving immune therapy.
•10. History of hypersensitivity to hyaluronic acid, lidocaine hydrochloride or other amidetype local anaesthetics.
•11. History of fish product allergy.