Pharmacokinetic Profiles of Subcutaneous Enoxaparin for Thromboprophylaxis in Critically Ill Patients With Renal Failure Treated or Not With Continuous Veno-veinous Hemofiltration.

Exclusion Criteria

• •Platelet count \< 50 000/μl.
• •CHILD PUGH stage C cirrhosis.
• •Known coagulation disorder.
• •Patient treated in the last 3 days with direct oral anticoagulants.
• •Patient treated in the last 24h with LMWH before enrollment.
• •High bleeding risk with contra indication for standard dose of LMWH prophylaxis, as per investigator judgment
• •Indication for therapeutic anticoagulation (including CVVH with systemic heparin anticoagulation).
• •Body weight \< 50 kg or \> 120 kg.
• •Evidence of recovery of renal function before enrollment, based on investigator judgement.