A Study of HRS-2129 in Patients With Diabetic Peripheral Neuropathic Pain

Exclusion Criteria

• •1. Subjects with a history of severe allergies.
• •2. Peripheral neuropathy or pain unrelated to diabetic peripheral neuropathy (DPN) that may confuse the assessment of diabetic peripheral neuropathic pain (DPNP).
• •3. Subjects with abnormal liver and renal function.
• •4. Corrected QT Interval (QTc): \> 450 ms (male), \> 470 ms (female).
• •5. Failure to response to previous treatment with pregabalin at doses ≥ 300 mg/d or gabapentin at doses ≥ 1200 mg/d for treatment of diabetic peripheral neuropathic pain (DPNP).
• •6. History of suicidal behavior or attempted suicide.
• •7. Participated in another clinical study within 3 months prior to screening.