Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic Study

Inclusion Criteria

• •Inpatients diagnosed with Major Depressive Disorder according to the International Classification of Diseases,11th Revision(ICD-11),and scheduled for Modified Electroconvulsive Therapy(MECT);
• •Aged 13 to 17 years,regardless of gender;
• •Educational attainment of primary school or higher;
• •Normal hearing and vision,including color perception;
• •Voluntary participation in the study with signed informed consent;
• •American Society of Anesthesiologists(ASA)physical status classification I-II.