Clareo Health | Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
Is 18 years or older for patients with established cardiovascular disease (CVD)
Is 55 years or older for patients with high risk for CVD
Has established CVD (defined as coronary, cerebrovascular, or peripheral artery disease) or high risk for CVD
Has treated hypertension on stable therapy with at least 2 standard of care antihypertensive medications, one of which must be a thiazide, thiazide-like, or loop diuretic
You may not be if
Has known history of secondary hypertension
Has symptomatic orthostatic hypotension
Has alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \>3×upper limit of normal (ULN)
Has total serum bilirubin \>1.5×ULN
Has international normalized ratio (INR) \>1.5
Has serum potassium \>4.8 mEq/L
Has estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73m\^2
