Hypertension Clinical Trials

Showing 1-20 of 3,361 trials

Reducing Inflammation to Improve Vascular and Bone Outcomes With Low-dose Colchicine in CKD

NCT07654231

The overall objective of this pilot randomized clinical trial is to determine whether low-dose Colchicine (LoDoCo) improves vascular disease including vascular calcification, peripheral arterial disease (PAD), and chronic kidney disease-mineral and bone disorder (CKD-MBD) biomarkers in patients with chronic kidney disease (CKD) stage 3 over a 12-month intervention period, compared with usual care. Successful completion of this study will generate critical preliminary data to support a larger clinical trial aimed at evaluating inflammation-targeted therapies to mitigate CKD-MBD, including vascular calcification and related PAD, as well as osteoporosis, ultimately reducing cardiovascular events and mortality in patients with CKD. Additionally, this work has the potential to redefine the diagnostic framework for CKD-MBD.

Chronic Kidney Disease Mineral and Bone DisorderHypertensionDiabetes+3 more

University of Texas Southwestern Medical Center60 participantsStarted Jul 2026

Dallas, Texas, United States

Not Yet RecruitingPhase 3

A Study to Evaluate Efficacy and Safety of HCP1803-4 in Patients With Essential Hypertension

NCT07660796

A Study to Evaluate Efficacy and Safety of HCP1803-4 in Patients With Essential Hypertension

Hypertension

Hanmi Pharmaceutical Company Limited256 participantsStarted Jul 2026

Goyang-si, Gyeonggi-do, South Korea

TERMINATEDPhase 4

Effects of Riociguat on RIght VEntricular Size and Function in PAH and CTEPH

NCT04954742

This is an open-label, single-armed, prospective single-centre clinical study to evaluate the effect of riociguat on right heart size and function in patients with manifest PAH and CTEPH.

Primary Pulmonary Arterial HypertensionChronic Thromboembolic Pulmonary Hypertension

Heidelberg University30 participantsStarted Apr 2022

Heidelberg, Germany

Reducing Inflammation to Improve Vascular and Bone Outcomes With Low-dose Colchicine in CKD

A Study to Evaluate Efficacy and Safety of HCP1803-4 in Patients With Essential Hypertension

Effects of Riociguat on RIght VEntricular Size and Function in PAH and CTEPH

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Clinical Trial to Evaluate the Pharmacokinetics and Safety Between the Single Administration of HL1113 and the Concomitant Administration of HL1113R1 and HL1113R2 for Healthy Subjects in Fasting State