Loading clinical trials...
Loading clinical trials...
Patients with pulmonary arterial hypertension (PAH) are at increased risk of muscle loss and decreased physical activity. This study will aim to (1) understand the way in which muscle loss occurs in PAH, particularly the role of fat surrounding the heart, and (2) look at the impact muscle loss has on quality of life, daily physical activity, and hospitalizations in patients with PAH. The findings from this study could help identify potentially treatable factors that may improve the overall quality of life and physical functioning of patients with PAH. Subjects will be asked to attend a baseline visit where the following will be performed: * Measure your vital signs * Undergo a research blood draw, less than 4 tablespoons * Provide a urine pregnancy test (if applicable) * Review demographics, personal history, and medical history * Review current PAH medications * Complete questionnaires on how your PAH affects you * Complete a test of physical performance * Complete a grip strength test * Undergo an echocardiogram (Echo) * Complete a six-minute walk test * Undergo a Chest CT Scan * Undergo a scan of your body composition (DXA scan) * Obtain a weight and body composition measurement on the InBody Scale Subjects will also complete activity moniotring, two 24-hour diet recalls, and participate in remote follow-up visits every 6 months
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
University of Pennsylvania Hospital
Philadelphia, Pennsylvania, United States
Start Date
May 1, 2025
Primary Completion Date
September 30, 2029
Completion Date
September 30, 2029
Last Updated
August 20, 2025
150
ESTIMATED participants
blood draw
DIAGNOSTIC_TEST
Short Performance Physical Battery
DIAGNOSTIC_TEST
Grip strength test
DIAGNOSTIC_TEST
Six minute walk test
DIAGNOSTIC_TEST
Chest CT scan
RADIATION
Dual-Energy X-ray Absorptiometry Scan
RADIATION
Activity monitoring
BEHAVIORAL
24 hour diet recall
BEHAVIORAL
Echocardiogram
DIAGNOSTIC_TEST
Quality of Life Questionnaire (emPHasis 10)
BEHAVIORAL
International Physical Activity Questionnaire Short Form (IPAQ-SF)
BEHAVIORAL
Lead Sponsor
University of Pennsylvania
Collaborators
NCT07073820
NCT06899815
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and ConditionsNCT07462260