Pharmacokinetics of Meropenem and Aztreonam After Intraperitoneal Administration Via Cycler-therapy in APD Patients Without Peritonitis

Exclusion Criteria

• •Any systemic infection
• •Peritonitis or catheter-related infection which required antibiotic treatment within 2 months prior to the start of the study
• •Allergy or hypersensitivity against study drug
• •Severe hepatic impairment (Child-Pugh Class C)
• •Pregnancy, or women of childbearing potential not willing to apply adequate contraception during study period
• •Any disease considered relevant for proper performance of the study or risks to the patient, at the discretion of the investigator
• •Hemoglobin below 9 g/dl
• •BMI below 19 or above 35