Comparing High and Low Dose Iron Treatments for People on Peritoneal Dialysis: The PALaDIN Study

Exclusion Criteria

• •Inadequate dialysis deemed by responsible clinician
• •Probability of need for transfusion within 1 week of enrolment
• •Anticipated major surgery that the responsible clinician feels will impact response to treatment
• •Haemochromatosis / haemosiderosis or ALT \>x3 normal
• •Are deemed to be most suited to best-supportive or end-of-life care at time of screening
• •Women of childbearing potential not using effective means of contraception
• •Have been involved in another medicinal study (CTIMP) within past 4 weeks
• •Known allergy or adverse reaction to oral or intravenous iron preparations
• •CRP \>50, TSATs \>40%, SF \>700 at time of recruitment
• •Active infection, HIV, active Hep B or C
• •Are unable or unwilling to consent to or complete the study procedures