Combining rTMS & Aerobic Exercise to Treat Depression and Improve Post-Stroke Walking

Exclusion Criteria

• •unable to ambulate at least 150 feet prior to stroke, or experienced intermittent claudication while walking
• •history of congestive heart failure, unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during ADL's
• •history of COPD or oxygen dependence
• •history of traumatic brain injury
• •blindness or severe visual impairment
• •history of psychosis or other Axis I disorder that is primary
• •life expectancy \<1 yr.
• •severe arthritis or problems that limit participation in testing or training
• •history of DVT or pulmonary embolism within 6 months
• •uncontrolled diabetes with recent weight loss, diabetic coma, or frequent insulin reactions
• •severe hypertension with systolic \>200 mmHg and diastolic \>110 mmHg at rest
• •attempt of suicide in the last 2 years or suicidal risk assessed by SCID
• •history of seizures or currently prescribed anti-seizure medications
• •current enrollment in a trial to enhance motor recovery
• •currently participating in behavioral treatment for depression
• •currently exercising ≥ 2 times per week (≥20 minutes)
• •contraindications to TMS
• •pregnancy or other contraindications to MRI.